Dose individualization of intravenous busulfan in pediatric patients undergoing bone marrow transplantation: impact and in vitro evaluation of infusion lag-time.

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第一作者： E,Neroutsos

第一单位： Laboratory of Biopharmaceutics & Pharmacokinetics, Department of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Athens, Greece.

作者： E,Neroutsos ^[1] ; I,Athanasiadou ^[1] ; A,Paisiou ^[2] ; K,Zisaki ^[2] ; E,Goussetis ^[2] ; H,Archontaki ^[3] ; P,Tsirigotis ^[4] ; M,Kitra ^[2] ; S,Grafakos ^[2] ; A,Spyridonidis ^[5] ; A,Dokoumetzidis ^[1] ; G,Valsami ^[1]

作者单位： Laboratory of Biopharmaceutics & Pharmacokinetics, Department of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Athens, Greece. ^[1] Bone Marrow Transplantation Unit, "Agia Sophia" General Children's Hospital of Athens, Athens, Greece. ^[2] Laboratory of Analytical Chemistry, Department of Chemistry, School of Sciences, National & Kapodistrian University of Athens, Athens, Greece. ^[3] Clinic of Internal Medicine, University Hospital "Attikon", Department of Medicine, School of Health Sciences, National & Kapodistrian University of Athens, Athens, Greece. ^[4] Bone Marrow Transplant Unit, University Hospital of Patras, Department of Medicine, School of Health Sciences, University of Patras, Rio, Patras, Greece. ^[5]

关键词 busulfan infusion lag-time pediatric population pharmacokinetics precision dosing therapeutic drug monitoring