Neurokinin Receptor 1 (NK1R) Antagonist Aprepitant Enhances Hematoma Clearance by Regulating Microglial Polarization via PKC/p38MAPK/NFκB Pathway After Experimental Intracerebral Hemorrhage in Mice.

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第一作者： Peng,Jin

第一单位： Department of Intensive Care Unit, Huashan Hospital, Fudan University, Shanghai, 200040, China.

作者： Peng,Jin ^[1] ; Shuixiang,Deng ^[2] ; Prativa,Sherchan ^[1] ; Yuhui,Cui ^[2] ; Lei,Huang ^[2] ; Gaigai,Li ^[2] ; Lifei,Lian ^[2] ; Shucai,Xie ^[3] ; Cameron,Lenahan ^[2] ; Zachary D,Travis ^[2] ; John H,Zhang ^[2] ; Ye,Gong ^[2] ; Jiping,Tang ^[4]

作者单位： Department of Intensive Care Unit, Huashan Hospital, Fudan University, Shanghai, 200040, China. ^[1] Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA. ^[2] Department of Neurosurgery, Loma Linda University, Loma Linda, CA, 92350, USA. ^[3] Burrell College of Osteopathic Medicine, Las Cruces, NM, 88001, USA. ^[4] Department of Anesthesiology, Loma Linda University, Loma Linda, CA, 92350, USA. ^[5] Department of Intensive Care Unit, Huashan Hospital, Fudan University, Shanghai, 200040, China. gong_ye@fudan.edu.cn. ^[6] Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. gong_ye@fudan.edu.cn. ^[7] Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA. jtang@llu.edu. ^[8]

关键词 Hematoma clearance Intracerebral hemorrhage Microglia polarization Neurokinin receptor-1 Thrombin