首页> Acta biomaterialia> Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells.

Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells.

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第一作者： Chun,Liu

第一单位： Orthopedic Research Institute/Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Guangzhou, China. Electronic address: liuch393@mail.sysu.edu.cn.

作者： Chun,Liu ^[1] ; Miao,Li ^[2] ; Zhao-Xia,Dong ^[3] ; Dong,Jiang ^[4] ; Xiaojing,Li ^[5] ; Shuibin,Lin ^[6] ; Demeng,Chen ^[6] ; Xuenong,Zou ^[7] ; Xing-Ding,Zhang ^[8] ; Gary D,Luker ^[9]

作者单位： Orthopedic Research Institute/Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Guangzhou, China. Electronic address: liuch393@mail.sysu.edu.cn. ^[1] The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, China. ^[2] Department of Pharmacology, Molecular Cancer Research Center, School of Medicine, Sun Yat-sen University, Shenzhen, China. ^[3] Orthopedic Research Institute/Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Guangzhou, China. ^[4] Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China. ^[5] Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. ^[6] Orthopedic Research Institute/Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Guangzhou, China. ^[7] Department of Pharmacology, Molecular Cancer Research Center, School of Medicine, Sun Yat-sen University, Shenzhen, China. Electronic address: zhangxd39@mail.sysu.edu.cn. ^[8] Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, United States. Electronic address: gluker@med.umich.edu. ^[9]

关键词 3D tumor model ECM stiffness Hybrid hydrogel Intratumor heterogeneity Tumor microenvironment

医学主题词乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);胶原(Collagen);细胞外基质(Extracellular Matrix);女(雌)性(Female);人类(Humans);水凝胶类(Hydrogels);肿瘤微环境(Tumor Microenvironment)

DOI 10.1016/j.actbio.2021.07.009

PMID 34246802

发布时间 2024-08-21

基金项目

R01 CA238042/CA/NCI NIH HHS/United States R01 CA238023/CA/NCI NIH HHS/United States R33 CA225549/CA/NCI NIH HHS/United States U01 CA210152/CA/NCI NIH HHS/United States R37 CA222563/CA/NCI NIH HHS/United States R01 CA196018/CA/NCI NIH HHS/United States

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