Paclitaxel anticancer activity is enhanced by the MEK 1/2 inhibitor PD98059 in vitro and by PD98059-loaded nanoparticles in BRAF<sup>V600E</sup> melanoma-bearing mice.

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第一作者： Aml I,Mekkawy

第一单位： Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA; Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, Sohag 82524, Egypt.

作者： Aml I,Mekkawy ^[1] ; Youssef W,Naguib ^[2] ; Suhaila O,Alhaj-Suliman ^[3] ; Emad I,Wafa ^[3] ; Kareem,Ebeid ^[2] ; Timothy,Acri ^[3] ; Aliasger K,Salem ^[4]

作者单位： Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA; Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, Sohag 82524, Egypt. ^[1] Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Minia 61519, Egypt; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Manufacturing, Deraya University, New Minia City, Minia 61768, Egypt. ^[2] Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA. ^[3] Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. Electronic address: aliasger-salem@uiowa.edu. ^[4]

关键词 BRAF mutation MEK1/2 Melanoma Nanoparticles PD98059 Paclitaxel