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首页> Bioorganic & medicinal chemistry letters> Necrostatins regulate apoptosis, necroptosis, and inflammation in cisplatin-induced nephrotoxicity in LLC-PK1 cells.

Necrostatins regulate apoptosis, necroptosis, and inflammation in cisplatin-induced nephrotoxicity in LLC-PK1 cells.

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作者： Dahae,Lee ^[1] ; Noriko,Yamabe ^[1] ; Heesu,Lee ^[2] ; Hye,Lim Lee ^[3] ; Dong-Wook,Kim ^[4] ; Jae,Wook Lee ^[5] ; Ki,Sung Kang ^[6]

作者单位： College of Korean Medicine, Gachon University, Seonngman 13120, Republic of Korea. ^[1] Department of Oral Anatomy, College of Dentistry, Gangneung Wonju National University, Gangneung, Republic of Korea. ^[2] Department of Pediatrics, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea. ^[3] Department of Pharmaceutical Engineering, Cheongju University, Cheongju 28530, Republic of Korea. ^[4] Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea; Convergent Research Center for Dementia, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: jwlee5@kist.re.kr. ^[5] College of Korean Medicine, Gachon University, Seonngman 13120, Republic of Korea. Electronic address: kkang@gachon.ac.kr. ^[6]

关键词 Acute kidney injury Apoptosis Caspase Cisplatin Mitogen-activated protein kinases Necrostatins

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);顺铂(Cisplatin);剂量效应关系, 药物(Dose-Response Relationship, Drug);上皮细胞(Epithelial Cells);咪唑类(Imidazoles);吲哚类(Indoles);炎症(Inflammation);肾小管(Kidney Tubules);LLC-PK1细胞(LLC-PK1 Cells);分子结构(Molecular Structure);小分子化合物库(Small Molecule Libraries);构效关系(Structure-Activity Relationship);猪(Swine)

DOI 10.1016/j.bmcl.2021.128256

PMID 34256117

发布时间 2022-01-04

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Bioorganic & medicinal chemistry letters

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