The intrinsic amyloidogenic propensity of cofilin-1 is aggravated by Cys-80 oxidation: A possible link with neurodegenerative diseases.

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作者： Vibha,Kaushik ^[1] ; Daniela,Brünnert ^[2] ; Eva-Maria,Hanschmann ^[3] ; Phulwanti Kumari,Sharma ^[1] ; Bibin G,Anand ^[4] ; Karunakar,Kar ^[4] ; Suneel,Kateriya ^[5] ; Pankaj,Goyal ^[6]

作者单位： Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandarsindri, Kishangarh, Rajasthan, 305 817, India. ^[1] Experimental Tumor Immunology, Department of Obstetrics and Gynecology, University of Würzburg Medical School, Würzburg, Germany. ^[2] Department of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Düsseldorf, Germany; Institute for Medical Biochemistry and Molecular Biology, University of Greifswald, 17475, Greifswald, Germany. ^[3] Biophysical and Biomaterials Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India. ^[4] School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India. ^[5] Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandarsindri, Kishangarh, Rajasthan, 305 817, India. Electronic address: pankaj_bio@curaj.ac.in. ^[6]

关键词 Actin dynamics Actin-cofilin rods Alzheimer's disease Amyloids Cofilin-1 Oxidative stress