Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling.

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第一作者： Yulin,He

第一单位： Institute of Biomedical Research, Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China.

作者： Yulin,He ^[1] ; Xingrong,Guo ^[2] ; Tingyu,Lan ^[1] ; Jianbo,Xia ^[2] ; Jinsong,Wang ^[1] ; Bei,Li ^[2] ; Chunyan,Peng ^[3] ; Yue,Chen ^[4] ; Xiang,Hu ^[5] ; Zhongji,Meng ^[6]

作者单位： Institute of Biomedical Research, Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. ^[1] Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan, 442000, Hubei, China. ^[2] Postgraduate Training Basement of Jinzhou Medical University, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. ^[3] Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. ^[4] Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, Hubei, China. ^[5] Shenzhen Beike Biotechnology Research Institute, Nanshan District, Shenzhen, 518057, China. ^[6] Shenzhen Beike Biotechnology Research Institute, Nanshan District, Shenzhen, 518057, China. huxiang@beike.cc. ^[7] Institute of Biomedical Research, Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. zhongji.meng@163.com. ^[8] Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan, 442000, Hubei, China. zhongji.meng@163.com. ^[9] Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. zhongji.meng@163.com. ^[10]

关键词 ACLF Liver fibrosis Liver injury Notch Paracrine Stat1 Stat3 hUC-MSCs