N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages.

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第一作者： Alessio,Menga

第一单位： Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.;Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.;Molecular Biotechnology Center, Turin, Italy.

作者： Alessio,Menga ^[1] ; Maria,Favia ^[2] ; Iolanda,Spera ^[3] ; Maria C,Vegliante ^[4] ; Rosanna,Gissi ^[3] ; Anna,De Grassi ^[3] ; Luna,Laera ^[3] ; Annalisa,Campanella ^[3] ; Andrea,Gerbino ^[3] ; Giovanna,Carrà ^[5] ; Marcella,Canton ^[6] ; Vera,Loizzi ^[7] ; Ciro L,Pierri ^[3] ; Gennaro,Cormio ^[8] ; Massimiliano,Mazzone ^[9] ; Alessandra,Castegna ^[10]

作者单位： Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.;Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.;Molecular Biotechnology Center, Turin, Italy. ^[1] Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.;Department of Biomedical Sciences, University of Padova, Padova, Italy. ^[2] Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy. ^[3] Haematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', Bari, Italy. ^[4] Molecular Biotechnology Center, Turin, Italy.;Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy. ^[5] Department of Biomedical Sciences, University of Padova, Padova, Italy.;Fondazione Istituto di Ricerca Pediatrica Città della Speranza - IRP, Padova, Italy. ^[6] Policlinico University of Bari "Aldo Moro", Bari, Italy. ^[7] Policlinico University of Bari "Aldo Moro", Bari, Italy.;Gynecologic Oncology Unit, IRCCS, Istituto Tumori Giovanni Paolo II, Bari, Italy. ^[8] Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.;Molecular Biotechnology Center, Turin, Italy.;Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium. ^[9] Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.;Fondazione Istituto di Ricerca Pediatrica Città della Speranza - IRP, Padova, Italy. ^[10]

关键词 IL-10 N-acetylaspartate TAMs metabolism ovarian cancer

主题词天冬氨酸(Aspartic Acid);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);人类(Humans);巨噬细胞(Macrophages);卵巢肿瘤(Ovarian Neoplasms);肿瘤微环境(Tumor Microenvironment)

DOI 10.15252/embr.202051981

PMID 34260142

发布时间 2024-09-06

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