Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation.

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第一作者： Anna-Lisa,Lanz

第一单位： T-cell signalling laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

作者： Anna-Lisa,Lanz ^[1] ; Giulia,Masi ^[1] ; Nicla,Porciello ^[1] ; André,Cohnen ^[1] ; Deborah,Cipria ^[1] ; Dheeraj,Prakaash ^[2] ; Štefan,Bálint ^[3] ; Roberto,Raggiaschi ^[1] ; Donatella,Galgano ^[1] ; David K,Cole ^[4] ; Marco,Lepore ^[5] ; Omer,Dushek ^[6] ; Michael L,Dustin ^[3] ; Mark S P,Sansom ^[7] ; Antreas C,Kalli ^[8] ; Oreste,Acuto ^[9]

作者单位： T-cell signalling laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. ^[1] Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK. ^[2] Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK. ^[3] Division Infection & Immunity, Cardiff University, Cardiff CF14 4XN, UK; Immunocore Ltd., Abingdon OX14 4RY, UK. ^[4] Immunocore Ltd., Abingdon OX14 4RY, UK. ^[5] Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. ^[6] Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address: mark.sansom@bioch.ox.ac.uk. ^[7] Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address: a.kalli@leeds.ac.uk. ^[8] T-cell signalling laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Electronic address: oreste.acuto@path.ox.ac.uk. ^[9]

关键词 T cell activation T cell antigen receptor adaptive immunity allosteric mechanism membrane signalling molecular dynamics simulation