首页> Journal of molecular and cellular cardiology> Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart.

Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart.

导出 OA

翻译打印收藏纠错

第一作者： Douglas J,Chapski

第一单位： Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA, United States of America.

作者： Douglas J,Chapski ^[1] ; Maximilian,Cabaj ^[1] ; Marco,Morselli ^[2] ; Rosibel J,Mason ^[1] ; Elizabeth,Soehalim ^[1] ; Shuxun,Ren ^[1] ; Matteo,Pellegrini ^[2] ; Yibin,Wang ^[3] ; Thomas M,Vondriska ^[3] ; Manuel,Rosa-Garrido ^[4]

作者单位： Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA, United States of America. ^[1] Department of Molecular, Cellular & Developmental Biology, David Geffen School of Medicine at UCLA, United States of America. ^[2] Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA, United States of America; Department of Medicine, David Geffen School of Medicine at UCLA, United States of America; Department of Physiology(,) David Geffen School of Medicine at UCLA, United States of America. ^[3] Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine at UCLA, United States of America. Electronic address: mrgarrido@mednet.ucla.edu. ^[4]

关键词 CTCF Chromatin accessibility DNA methylation Enhancers Heart failure

医学主题词动物(Animals);心脏扩大(Cardiomegaly);染色质(Chromatin);染色质组装和分解(Chromatin Assembly and Disassembly);DNA甲基化(DNA Methylation);疾病模型, 动物(Disease Models, Animal);增强子元件, 遗传学(Enhancer Elements, Genetic);后成说, 遗传(Epigenesis, Genetic);基因表达(Gene Expression);心力衰竭(Heart Failure);组蛋白类(Histones);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);肌细胞, 心脏(Myocytes, Cardiac);表型(Phenotype);启动区, 遗传(Promoter Regions, Genetic);大鼠(Rats);转录因子(Transcription Factors)

DOI 10.1016/j.yjmcc.2021.07.002

PMID 34273410

发布时间 2022-07-16

基金项目

R01 HL143058/HL/NHLBI NIH HHS/United States R01 HL105699/HL/NHLBI NIH HHS/United States R01 HL150225/HL/NHLBI NIH HHS/United States R01 HL129639/HL/NHLBI NIH HHS/United States R21 HL150667/HL/NHLBI NIH HHS/United States

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交