Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19: A Randomized Clinical Trial.

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作者： Roberto,Caricchio ^[1] ; Antonio,Abbate ^[2] ; Ivan,Gordeev ^[3] ; Jamie,Meng ^[4] ; Priscilla Y,Hsue ^[5] ; Tuhina,Neogi ^[6] ; Roberto,Arduino ^[7] ; Daria,Fomina ^[8] ; Roman,Bogdanov ^[9] ; Tatiana,Stepanenko ^[10] ; Pilar,Ruiz-Seco ^[11] ; Andrés,Gónzalez-García ^[12] ; Yu,Chen ^[13] ; Yuhan,Li ^[14] ; Sarah,Whelan ^[14] ; Stephanie,Noviello ^[15] ; CAN-COVID Investigators ^[14]

作者单位： Division of Rheumatology, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania. ^[1] Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond. ^[2] City Clinical Hospital No. 15 Named After O.M. Filatov, Moscow, Russian Federation. ^[3] Maimonides Medical Center, Brooklyn, New York. ^[4] University of California, San Francisco, Zuckerberg San Francisco General Hospital, San Francisco. ^[5] Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts. ^[6] McGovern Medical School at The University of Texas Health Science Center at Houston. ^[7] Center of Allergy and Immunology, Clinical City Hospital No. 52, Moscow, Russian Federation. ^[8] Department of Allergy and Clinical Immunology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. ^[9] Therapeutic Department, Aleksandrovskaya Hospital, St Petersburg, Russian Federation. ^[10] City Multi-specialty Hospital No. 2, St Petersburg, Russian Federation. ^[11] Unidad Medicina Interna, Hospital Universitario Infanta Sofía, Madrid, Spain. ^[12] Unidad de Enfermedades Sistémicas Autoinmunes y Minoritarias, Servicio de Medicina Interna, Hospital Ramón y Cajal, Madrid, Spain. ^[13] Novartis Pharmaceuticals Corporation, East Hanover, New Jersey. ^[14] Novartis Ireland Ltd, Dublin, Ireland. ^[15]