Evaluation of release and pharmacokinetics of hexadecylphosphocholine (miltefosine) in phosphatidyldiglycerol-based thermosensitive liposomes.

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作者： Alexander,Rysin ^[1] ; Michael,Paal ^[2] ; Wouter J M,Lokerse ^[3] ; Barbara,Wedmann ^[4] ; Martin,Hossann ^[4] ; Michael,Vogeser ^[2] ; Gerhard,Winter ^[5] ; Lars H,Lindner ^[6]

作者单位： Department of Medicine III, University Hospital, LMU Munich, Germany; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, LMU Munich, Germany. ^[1] Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany. ^[2] Department of Medicine III, University Hospital, LMU Munich, Germany. ^[3] Thermosome GmbH, Am Klopferspitz 19, Planegg, Germany. ^[4] Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, LMU Munich, Germany. ^[5] Department of Medicine III, University Hospital, LMU Munich, Germany. Electronic address: lars.lindner@med.uni-muenchen.de. ^[6]

关键词 Alkyphospholipids Hexadecylphosphocholine Hyperthermia Lipophilic drug Miltefosine Multilamellar vesicles Temperature-dependent release Thermosensitive liposomes

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);量热法, 差式扫描(Calorimetry, Differential Scanning);色谱法, 液相(Chromatography, Liquid);溶血(Hemolysis);人类(Humans);脂质体(Liposomes);男(雄)性(Male);磷脂酰甘油类(Phosphatidylglycerols);磷酰胆碱(Phosphorylcholine);大鼠(Rats);串联质谱法(Tandem Mass Spectrometry);温度(Temperature)

DOI 10.1016/j.bbamem.2021.183698

PMID 34283999

发布时间 2021-11-17

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Biochimica et biophysica acta. Biomembranes

2021年1863卷11期

183698页

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Evaluation of release and pharmacokinetics of hexadecylphosphocholine (miltefosine) in phosphatidyldiglycerol-based thermosensitive liposomes.

Biochimica et biophysica acta. Biomembranes

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Biochimica et biophysica acta. Biomembranes

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Evaluation of release and pharmacokinetics of hexadecylphosphocholine (miltefosine) in phosphatidyldiglycerol-based thermosensitive liposomes.

Biochimica et biophysica acta. Biomembranes

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Biochimica et biophysica acta. Biomembranes

相关期刊

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