首页> Cell reports> Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.

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第一作者： J,Kempf

第一单位： Biomedical Center Munich, Physiological Genomics, LMU Munich, Planegg-Martinsried 82152, Germany.

作者： J,Kempf ^[1] ; K,Knelles ^[1] ; B A,Hersbach ^[2] ; D,Petrik ^[3] ; T,Riedemann ^[1] ; V,Bednarova ^[1] ; A,Janjic ^[4] ; T,Simon-Ebert ^[1] ; W,Enard ^[5] ; P,Smialowski ^[3] ; M,Götz ^[6] ; G,Masserdotti ^[7]

作者单位： Biomedical Center Munich, Physiological Genomics, LMU Munich, Planegg-Martinsried 82152, Germany. ^[1] Biomedical Center Munich, Physiological Genomics, LMU Munich, Planegg-Martinsried 82152, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, Neuherberg 85764, Germany; Graduate School of Systemic Neurosciences, LMU Munich, Planegg-Martinsried 82152, Germany. ^[2] Biomedical Center Munich, Physiological Genomics, LMU Munich, Planegg-Martinsried 82152, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, Neuherberg 85764, Germany; School of Biosciences, The Sir Martin Evans Building, Cardiff University, CF10 3AX Cardiff, UK. ^[3] Anthropology and Human Genomics, Faculty of Biology, LMU Munich, Planegg-Martinsried 82152, Germany. ^[4] Biomedical Center Munich, Bioinformatic Core Facility, LMU Munich, Planegg-Martinsried 82152, Germany. ^[5] Biomedical Center Munich, Physiological Genomics, LMU Munich, Planegg-Martinsried 82152, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, Neuherberg 85764, Germany; Excellence Cluster of Systems Neurology (SYNERGY), Munich, Germany. Electronic address: magdalena.goetz@helmholtz-muenchen.de. ^[6] Biomedical Center Munich, Physiological Genomics, LMU Munich, Planegg-Martinsried 82152, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, Neuherberg 85764, Germany. Electronic address: giacomo.masserdotti@helmholtz-muenchen.de. ^[7]

关键词 Ascl1 Neurog2 astrocytes direct reprogramming patch-seq patterning genes single-cell RNA-seq spinal cord