Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts.

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第一作者： Anthony B,Rodriguez

第一单位： Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

作者： Anthony B,Rodriguez ^[1] ; J David,Peske ^[1] ; Amber N,Woods ^[1] ; Katie M,Leick ^[2] ; Ileana S,Mauldin ^[2] ; Max O,Meneveau ^[3] ; Samuel J,Young ^[2] ; Robin S,Lindsay ^[1] ; Marit M,Melssen ^[2] ; Salwador,Cyranowski ^[4] ; Geoffrey,Parriott ^[4] ; Mark R,Conaway ^[5] ; Yang-Xin,Fu ^[6] ; Craig L,Slingluff ^[2] ; Victor H,Engelhard ^[7]

作者单位： Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[1] Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[2] Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[3] Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[4] Division of Translational Research & Applied Statistics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[5] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. ^[6] Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: vhe@virginia.edu. ^[7]

关键词 B lymphocytes B16 melanoma CD8?T lymphocytes cancer-associated fibroblasts checkpoint blockade immunotherapy lymphoid tissue inducer cell lymphoid tissue organizer cell lymphotoxin-β receptor tertiary lymphoid structure tumor necrosis factor receptor