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首页> Toxicology in vitro : an international journal published in association with BIBRA> Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation.

Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation.

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第一作者： Tao,Liu

第一单位： Department of Neurology, University of Chinese Academy of Sciences Shenzhen Hospital (Guang ming), No. 39 Huaxia Road, Guangming District, Shenzhen 518107, China.

作者： Tao,Liu ^[1] ; Xuegang,Wang ^[2] ; Feng,Guo ^[1] ; Xiaobo,Sun ^[3] ; Kunxiong,Yuan ^[1] ; Qingyong,Wang ^[1] ; Chunwei,Lan ^[4]

作者单位： Department of Neurology, University of Chinese Academy of Sciences Shenzhen Hospital (Guang ming), No. 39 Huaxia Road, Guangming District, Shenzhen 518107, China. ^[1] Department of Hepatology, The People's Hospital of Bao an, No. 118, Longjing Second Road, Baoan District, Shenzhen 518107, China. ^[2] Department of Laboratory Diagnostics, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. ^[3] Department of Neurology, University of Chinese Academy of Sciences Shenzhen Hospital (Guang ming), No. 39 Huaxia Road, Guangming District, Shenzhen 518107, China. Electronic address: lancwei@163.com. ^[4]

关键词 Apoptosis Brain microvascular endothelial cells G protein-coupled receptor 4 Lysophosphatidylcholine NLRP3 inflammasome

主题词细胞凋亡(Apoptosis);脑(Brain);细胞系(Cell Line);内皮, 血管(Endothelium, Vascular);人类(Humans);炎性体(Inflammasomes);溶血磷脂酰胆碱类(Lysophosphatidylcholines);微血管(Microvessels);受体, G-蛋白偶联(Receptors, G-Protein-Coupled)

DOI 10.1016/j.tiv.2021.105227

PMID 34293432

发布时间 2022-02-03

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