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首页> Stem cell research & therapy> The tRNA-derived fragment 5026a inhibits the proliferation of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway.

The tRNA-derived fragment 5026a inhibits the proliferation of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway.

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作者： Linwen,Zhu ^[1] ; Zhe,Li ^[2] ; Xiuchong,Yu ^[3] ; Yao,Ruan ^[1] ; Yijing,Shen ^[2] ; Yongfu,Shao ^[2] ; Xinjun,Zhang ^[2] ; Guoliang,Ye ^[2] ; Junming,Guo ^[1]

作者单位： Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China. ^[1] Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China. ^[2] Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315041, China. ^[3] Institute of Digestive Diseases of Ningbo University, Ningbo, 315020, China. ^[4] Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China. guojunming@nbu.edu.cn. ^[5] Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China. guojunming@nbu.edu.cn. ^[6] Institute of Digestive Diseases of Ningbo University, Ningbo, 315020, China. guojunming@nbu.edu.cn. ^[7]

关键词 Gastric cancer PI3K PTEN tRF-18-79MP9P04 tRF-5026a tRNA-derived small RNAs

主题词动物(Animals);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);小鼠(Mice);小鼠, 裸(Mice, Nude);PTEN磷酸水解酶(PTEN Phosphohydrolase);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);RNA, 转移(RNA, Transfer);信号传导(Signal Transduction);胃肿瘤(Stomach Neoplasms)

DOI 10.1186/s13287-021-02497-1

PMID 34294122

发布时间 2021-08-06

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Stem cell research & therapy

Stem cell research & therapy

2021年12卷1期

418页

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