Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.

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第一作者： Christopher L,Hartl

第一单位： Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, USA.

作者： Christopher L,Hartl ^[1] ; Gokul,Ramaswami ^[2] ; William G,Pembroke ^[2] ; Sandrine,Muller ^[2] ; Greta,Pintacuda ^[3] ; Ashis,Saha ^[4] ; Princy,Parsana ^[3] ; Alexis,Battle ^[5] ; Kasper,Lage ^[6] ; Daniel H,Geschwind ^[6]

作者单位： Interdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, USA. ^[1] Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[2] Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[3] Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. ^[4] Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA, USA. ^[5] Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA. ^[6] Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. ^[7] Institute for Biological Psychiatry, Mental Health Center Sct. Hans, University of Copenhagen, Roskilde, Denmark. ^[8] Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. dhg@mednet.ucla.edu. ^[9] Department of Psychiatry and Biobehavioral Sciences, Semel Institue, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. dhg@mednet.ucla.edu. ^[10] Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. dhg@mednet.ucla.edu. ^[11] Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. dhg@mednet.ucla.edu. ^[12]

主题词脑(Brain);基因表达谱(Gene Expression Profiling);基因调控网络(Gene Regulatory Networks);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);精神障碍(Mental Disorders)

DOI 10.1038/s41593-021-00887-5

PMID 34294919

发布时间 2023-11-02

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