Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit.

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作者： Alessandro,Tozzi ^[1] ; Miriam,Sciaccaluga ^[1] ; Vittorio,Loffredo ^[1] ; Alfredo,Megaro ^[2] ; Ada,Ledonne ^[1] ; Antonella,Cardinale ^[3] ; Mauro,Federici ^[4] ; Laura,Bellingacci ^[5] ; Silvia,Paciotti ^[3] ; Elena,Ferrari ^[1] ; Antonino,La Rocca ^[1] ; Alessandro,Martini ^[6] ; Nicola B,Mercuri ^[2] ; Fabrizio,Gardoni ^[3] ; Barbara,Picconi ^[3] ; Veronica,Ghiglieri ^[7] ; Elvira,De Leonibus ^[6] ; Paolo,Calabresi ^[4]

作者单位： Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy. ^[1] Institute of Biochemistry and Cell Biology - IBBC, CNR, 00015 Monterotondo scalo, Italy. ^[2] Laboratory of Experimental Neuroscience, Santa Lucia Foundation IRCCS, 00143 Rome, Italy. ^[3] Department of Experimental Neurophysiology, IRCCS San Raffaele, 00166 Rome, Italy. ^[4] Neurology, Department of Neuroscience, Faculty of Medicine, Università Cattolica del "Sacro Cuore", 00168 Rome, Italy. ^[5] Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy. ^[6] Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy. ^[7] San Raffaele University, 00166 Rome, Italy. ^[8] Telethon Institute of Genetics and Medicine, 80078 Pozzuoli, Italy. ^[9] Neurological Clinic, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy. ^[10]

关键词 Parkinson’s disease long-term depression long-term potentiation substantia nigra synaptic plasticity