Encapsulation of a highly hydrophilic drug in polymeric particles: A comparative study of batch and microfluidic processes.

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作者： Sarah S,Aboelela ^[1] ; Mariam,Ibrahim ^[2] ; Abu Zayed M,Badruddoza ^[2] ; Valerie,Tran ^[2] ; James K,Ferri ^[2] ; Thomas D,Roper ^[3]

作者单位： Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Chemical and Life Science Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23220, USA. ^[1] Chemical and Life Science Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23220, USA. ^[2] Chemical and Life Science Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23220, USA. Electronic address: tdroper@vcu.edu. ^[3]

关键词 Design of experiments Double emulsion Hydrophilic drug encapsulation Metformin hydrochloride Microfluidics PLGA Polymeric particles Solvent evaporation

主题词药物载体(Drug Carriers);乳状剂(Emulsions);微流体学(Microfluidics);微球体(Microspheres);粒子大小(Particle Size);聚合物(Polymers)

DOI 10.1016/j.ijpharm.2021.120906

PMID 34298100

发布时间 2021-09-07

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