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Ultrasound-assisted theophylline polymorphic transformation: Selective polymorph nucleation, molecular mechanism and kinetics analysis.

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第一作者： Chen,Fang

第一单位： School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China; The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China.

作者： Chen,Fang ^[1] ; Peng,Yang ^[1] ; Yumin,Liu ^[1] ; Jingkang,Wang ^[1] ; Zhenguo,Gao ^[2] ; Junbo,Gong ^[3] ; Sohrab,Rohani ^[4]

作者单位： School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China; The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China. ^[1] School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China; The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China. Electronic address: zhenguogao@tju.edu.cn. ^[2] School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China; The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China. Electronic address: junbo_gong@tju.edu.cn. ^[3] Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada. ^[4]

关键词 Polymorph Solute-solvent interaction Theophylline Transformation kinetics Ultrasound

医学主题词茶碱(Theophylline);动力学(Kinetics);模型, 分子(Models, Molecular);结晶(Crystallization);溶剂(Solvents);分子构象(Molecular Conformation)

DOI 10.1016/j.ultsonch.2021.105675

PMID 34298309

发布时间 2024-07-24

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