Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer.

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作者： Long,Jiao ^[1] ; Roman,Eickhoff ^[1] ; Antje,Egners ^[1] ; Sandra,Jumpertz ^[1] ; Johanna,Roth ^[1] ; Merve,Erdem ^[1] ; Andreas,Kroh ^[1] ; Hans,Duimel ^[2] ; Carmen,López-Iglesias ^[2] ; Pilar,Caro ^[1] ; Lara R,Heij ^[1] ; Maximilian,Schmeding ^[3] ; David,Meierhofer ^[1] ; Ulf P,Neumann ^[4] ; Thorsten,Cramer ^[1]

作者单位： Department of General, Visceral- and Transplantation Surgery, RWTH University Hospital, Aachen, Germany. ^[1] Microscopy Core Lab, FHML and M4I Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands. ^[2] Pathology, RWTH University Hospital, Aachen, Germany. ^[3] Max Planck Institute for Molecular Genetics, Berlin, Germany. ^[4] ESCAM - European Surgery Center Aachen Maastricht, Aachen, Germany. ^[5] ESCAM - European Surgery Center Aachen Maastricht, Maastricht, The Netherlands. ^[6] Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands. ^[7] NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. ^[8]

关键词 NF-κB colon cancer inflammation liver metastasis liver regeneration mTOR necroptosis