Natural molecule Munronoid I attenuates LPS-induced acute lung injury by promoting the K48-linked ubiquitination and degradation of TAK1.
第一作者:
Xingyu,Ma
第一单位:
Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Shenzhen University School of Medicine, Shenzhen 518060, PR China.
作者:
主题词
急性肺损伤(Acute Lung Injury);动物(Animals);消炎药(Anti-Inflammatory Agents);环氧化酶2(Cyclooxygenase 2);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);HEK293细胞(HEK293 Cells);人类(Humans);炎症介导素类(Inflammation Mediators);柠檬苦素类(Limonins);脂多糖类(Lipopolysaccharides);肺(Lung);MAP激酶激酶激酶类(MAP Kinase Kinase Kinases);巨噬细胞, 腹膜(Macrophages, Peritoneal);小鼠, 近交C57BL(Mice, Inbred C57BL);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);磷酰化(Phosphorylation);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);泛素化(Ubiquitination);小鼠(Mice)
DOI
10.1016/j.biopha.2021.111543
PMID
34311538
发布时间
2024-02-26
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