Lorlatinib Induces Durable Disease Stabilization in a Pancreatic Cancer Patient with a ROS1 p.L1950F Mutation: Case Report.

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作者： Janna-Lisa,Velthaus ^[1] ; Peter,Iglauer ^[2] ; Ronald,Simon ^[2] ; Carsten,Bokemeyer ^[3] ; Peter,Bannas ^[4] ; Niklas,Beumer ^[5] ; Charles D,Imbusch ^[6] ; Eray,Goekkurt ^[7] ; Sonja,Loges ^[6]

作者单位： Department of Hematology, Oncology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, j.velthaus@uke.de. ^[1] Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[2] Department of Hematology, Oncology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[3] Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany. ^[4] Division of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[5] Division of Applied Bioinformatics (B330), German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[6] Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. ^[7] Hematology-Oncology Practice Hamburg (HOPE), Hamburg, Germany. ^[8] Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. ^[9]

关键词 Lorlatinib Pancreatic cancer Precision oncology ROS1

主题词氨基吡啶类(Aminopyridines);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);人类(Humans);内酰胺类(Lactams);肺肿瘤(Lung Neoplasms);突变(Mutation);胰腺肿瘤(Pancreatic Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);原癌基因蛋白质类(Proto-Oncogene Proteins);吡唑类(Pyrazoles)

DOI 10.1159/000517616

PMID 34320493

发布时间 2021-12-04

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Oncology research and treatment

2021年44卷9期

495-502页

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Lorlatinib Induces Durable Disease Stabilization in a Pancreatic Cancer Patient with a ROS1 p.L1950F Mutation: Case Report.

Oncology research and treatment

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Lorlatinib Induces Durable Disease Stabilization in a Pancreatic Cancer Patient with a ROS1 p.L1950F Mutation: Case Report.

Oncology research and treatment

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Oncology research and treatment

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