A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.-论文-万方医学网

第一作者： Sohaib,Nizami

第一单位： Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.;Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.

作者： Sohaib,Nizami ^[1] ; Val,Millar ^[2] ; Kanisa,Arunasalam ^[1] ; Tryfon,Zarganes-Tzitzikas ^[1] ; David,Brough ^[3] ; Gary,Tresadern ^[4] ; Paul E,Brennan ^[1] ; John B,Davis ^[1] ; Daniel,Ebner ^[5] ; Elena,Di Daniel ^[6]

作者单位： Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.;Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. ^[1] Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.;Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.;National Phenotypic Screening Centre, Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. ^[2] Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.;Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, M13 9PT, UK. ^[3] Janssen Research and Development, Turnhoutseweg 30, 2340, Beerse, Belgium. ^[4] Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. daniel.ebner@ndm.ox.ac.uk.;National Phenotypic Screening Centre, Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. daniel.ebner@ndm.ox.ac.uk. ^[5] Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. elena.di-daniel@astx.com.;Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. elena.di-daniel@astx.com. ^[6]

医学主题词动物(Animals);CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins);半胱氨酸天冬氨酸蛋白酶1(Caspase 1);细胞, 培养的(Cells, Cultured);二甲亚砜(Dimethyl Sulfoxide);药物发现(Drug Discovery);药物评价, 临床前(Drug Evaluation, Preclinical);呋喃类(Furans);基因, 报告(Genes, Reporter);高通量筛选分析(High-Throughput Screening Assays);茚类(Indenes);炎性体(Inflammasomes);白细胞介素1β(Interleukin-1beta);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);小鼠(Mice);尼日利亚菌素(Nigericin);表型(Phenotype);重组蛋白质类(Recombinant Proteins);小分子化合物库(Small Molecule Libraries);磺胺类(Sulfonamides)

DOI 10.1038/s41598-021-94850-w

PMID 34321581

发布时间 2021-12-14

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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.

Scientific reports

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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.

Scientific reports

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Scientific reports

相关期刊

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