Mild Hyperhomocysteinemia Causes Anxiety-like Behavior and Brain Hyperactivity in Rodents: Are ATPase and Excitotoxicity by NMDA Receptor Overstimulation Involved in this Effect?

导出 LinkOut

翻译打印收藏纠错

作者： Tiago Marcon,Dos Santos ^[1] ; Cassiana,Siebert ^[2] ; Larissa Daniele,Bobermin ^[1] ; André,Quincozes-Santos ^[2] ; Angela T S,Wyse ^[2]

作者单位： Wyse´s Lab, Institute of Health Basic Sciences, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil. ^[1] Postgraduate Program in Biological Science: Biochemistry, Institute of Health Basic Sciences, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil. ^[2] Department of Biochemistry, Institute of Health Basic Sciences, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil. ^[3] Wyse´s Lab, Institute of Health Basic Sciences, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil. wyse@ufrgs.br. ^[4] Postgraduate Program in Biological Science: Biochemistry, Institute of Health Basic Sciences, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil. wyse@ufrgs.br. ^[5] Department of Biochemistry, Institute of Health Basic Sciences, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil. wyse@ufrgs.br. ^[6]

关键词 Anxiety disorders Cell survival Glutamate homeostasis Mild hyperhomocysteinemia N-Methyl-D-Aspartate Receptors Sodium–Potassium-exchanging ATPase