Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.

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作者： Feng,Jing ^[1] ; Qian,Zou ^[2] ; Yangyang,Wang ^[3] ; Zhiyou,Cai ^[3] ; Yong,Tang ^[4]

作者单位： Department of Histology and Embryology, Chongqing Medical University, No.1 Yixueyuan Road, Yuzhong District, 400016, Chongqing, China. ^[1] Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, No.118 Xingguang Avenue, Liangjiang New Area, 401147, Chongqing, China. ^[2] Chongqing Key Laboratory of Neurodegenerative Diseases, No.312 Zhongshan First Road, Yuzhong District, 400013, Chongqing, China. ^[3] Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, No.118 Xingguang Avenue, Liangjiang New Area, 401147, Chongqing, China. caizhiyou@ucas.ac.cn. ^[4] Chongqing Key Laboratory of Neurodegenerative Diseases, No.312 Zhongshan First Road, Yuzhong District, 400013, Chongqing, China. caizhiyou@ucas.ac.cn. ^[5] Department of Histology and Embryology, Chongqing Medical University, No.1 Yixueyuan Road, Yuzhong District, 400016, Chongqing, China. ytang062@163.com. ^[6]

关键词 Central sensitization Chronic migraine GLP-1 receptor Microglia Nitroglycerin Trigeminal nucleus caudalis

主题词动物(Animals);小鼠(Mice);小神经胶质细胞(Microglia);偏头痛(Migraine Disorders);硝酸甘油(Nitroglycerin);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);三叉神经核(Trigeminal Nuclei)

DOI 10.1186/s10194-021-01302-x

PMID 34325647

发布时间 2021-08-02

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准确一般字义偏差语意偏离译文作用小提交