Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma.

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作者： Elisa,De Crignis ^[1] ; Tanvir,Hossain ^[1] ; Shahla,Romal ^[1] ; Fabrizia,Carofiglio ^[1] ; Panagiotis,Moulos ^[2] ; Mir Mubashir,Khalid ^[1] ; Shringar,Rao ^[1] ; Ameneh,Bazrafshan ^[1] ; Monique Ma,Verstegen ^[3] ; Farzin,Pourfarzad ^[4] ; Christina,Koutsothanassis ^[5] ; Helmuth,Gehart ^[6] ; Tsung Wai,Kan ^[1] ; Robert-Jan,Palstra ^[1] ; Charles,Boucher ^[7] ; Jan Nm,IJzermans ^[3] ; Meritxell,Huch ^[8] ; Sylvia F,Boj ^[4] ; Robert,Vries ^[4] ; Hans,Clevers ^[6] ; Luc Jw,van der Laan ^[3] ; Pantelis,Hatzis ^[2] ; Tokameh,Mahmoudi ^[1]

作者单位： Department of Biochemistry, Erasmus University Medical Center, Rotterdam, Netherlands. ^[1] Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece. ^[2] Department of Surgery, Erasmus University Medical Center, Rotterdam, Netherlands. ^[3] Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands. ^[4] HybridStat Predictive Analytics, Kifisia, Greece. ^[5] Hubrecht Institute-KNAW, University Medical Centre Utrecht, Utrecht, Netherlands. ^[6] Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands. ^[7] Max Plank Institute of Molecular Cell Biology and Genetics, Dresden, Germany. ^[8] Department of Urology, Erasmus University Medical Center, Rotterdam, Netherlands. ^[9] Department of Pathology, Erasmus University Medical Center, Rotterdam, Netherlands. ^[10]

关键词 Hepatitis B virus hepatocellular carcinoma human infectious disease liver organoids microbiology