Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs.

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作者： Halil I,Ciftci ^[1] ; Nilüfer,Bayrak ^[2] ; Mahmut,Yıldız ^[3] ; Hatice,Yıldırım ^[2] ; Belgin,Sever ^[4] ; Hiroshi,Tateishi ^[5] ; Masami,Otsuka ^[1] ; Mikako,Fujita ^[6] ; Amaç Fatih,Tuyun ^[7]

作者单位： Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan. ^[1] Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey. ^[2] Chemistry Department, Gebze Technical University, Gebze, Kocaeli, Turkey. ^[3] Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey. ^[4] Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan. ^[5] Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan. Electronic address: mfujita@kumammot-u.ac.jp. ^[6] Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey. Electronic address: aftuyun@istanbul.edu.tr. ^[7]

关键词 Apoptosis Chronic myelogenous leukemia (CML)DNA-cleavage LY83583 Quinolinequinone, Aminoquinone