PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.

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作者： Yuezheng,Zhang ^[1] ; Brendan F,Kohrn ^[1] ; Ming,Yang ^[1] ; Daniela,Nachmanson ^[1] ; T Rinda,Soong ^[1] ; I-Hsiu,Lee ^[2] ; Yong,Tao ^[3] ; Hans,Clevers ^[4] ; Elizabeth M,Swisher ^[5] ; Teresa A,Brentnall ^[6] ; Lawrence A,Loeb ^[7] ; Scott R,Kennedy ^[8] ; Jesse J,Salk ^[1] ; Kamila,Naxerova ^[1] ; Rosa Ana,Risques ^[9]

作者单位： Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195. ^[1] Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114. ^[2] Department of Radiology, Harvard Medical School, Boston, MA 02114. ^[3] Division of Human Biology, Fred Hutchinson Cancer Research Center, WA 98019. ^[4] Division of Clinical Research, Fred Hutchinson Cancer Research Center, WA 98019. ^[5] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, Netherlands. ^[6] Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington Medical Center, Seattle, WA 98195. ^[7] Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA 98195. ^[8] Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98195. ^[9] Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195; rrisques@uw.edu. ^[10]

关键词 cancer evolution carcinogenic fields phylogenetic reconstruction preneoplastic somatic evolution