Activity of β-lactam plus β-lactam-enhancer combination cefepime/zidebactam against Klebsiella pneumoniae harbouring defective OmpK35/36 porins and carbapenemases.

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作者： Prashant,Joshi ^[1] ; Rahul,Shrivastava ^[1] ; Sachin,Bhagwat ^[2] ; Mahesh,Patel ^[1]

作者单位： Drug Discovery Research, Wockhardt Research Center, Aurangabad, Maharashtra, India. ^[1] Drug Discovery Research, Wockhardt Research Center, Aurangabad, Maharashtra, India. Electronic address: sbhagwat@wockhardt.com. ^[2]

关键词 Carbapenemases Klebsiella pneumoniae Outer membrane porins Zidebactam β-lactam enhancer

主题词抗菌药(Anti-Bacterial Agents);氮杂双环化合物(Azabicyclo Compounds);细菌蛋白质类(Bacterial Proteins);卡巴配能类(Carbapenems);头孢菌素类(Cephalosporins);环辛烷类(Cyclooctanes);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);人类(Humans);克雷伯菌感染(Klebsiella Infections);肺炎克雷伯菌(Klebsiella pneumoniae);微生物敏感性试验(Microbial Sensitivity Tests);突变(Mutation);孔蛋白质类(Porins);β-内酰胺酶类(beta-Lactamases);β内酰胺类(beta-Lactams)

DOI 10.1016/j.diagmicrobio.2021.115481

PMID 34332307

发布时间 2021-11-01

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Diagnostic microbiology and infectious disease

2021年101卷2期

115481页

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Activity of β-lactam plus β-lactam-enhancer combination cefepime/zidebactam against Klebsiella pneumoniae harbouring defective OmpK35/36 porins and carbapenemases.

Diagnostic microbiology and infectious disease

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Diagnostic microbiology and infectious disease

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Activity of β-lactam plus β-lactam-enhancer combination cefepime/zidebactam against Klebsiella pneumoniae harbouring defective OmpK35/36 porins and carbapenemases.

Diagnostic microbiology and infectious disease

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Diagnostic microbiology and infectious disease

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