A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.

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作者： Swetha,Raman ^[1] ; Samantha N,Buongervino ^[2] ; Maria V,Lane ^[2] ; Doncho V,Zhelev ^[3] ; Zhongyu,Zhu ^[4] ; Hong,Cui ^[1] ; Benjamin,Martinez ^[1] ; Daniel,Martinez ^[5] ; Yanping,Wang ^[4] ; Kristen,Upton ^[2] ; Khushbu,Patel ^[2] ; Komal S,Rathi ^[6] ; Carmen T,Navia ^[7] ; Daniel B,Harmon ^[7] ; Yimei,Li ^[8] ; Bruce,Pawel ^[9] ; Dimiter S,Dimitrov ^[10] ; John M,Maris ^[3] ; Jean-Philippe,Julien ^[2] ; Kristopher R,Bosse ^[11]

作者单位： Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada. ^[1] Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. ^[2] Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[3] Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA. ^[4] Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. ^[5] Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. ^[6] Integral Molecular, Philadelphia, PA 19104, USA. ^[7] Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[8] Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. ^[9] Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA. ^[10] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. ^[11] Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[12]

关键词 MYCN antibody-drug conjugate glypican neuroblastoma small-cell lung cancer

主题词动物(Animals);旁观者效应(Bystander Effect);细胞区室化(Cell Compartmentation);细胞死亡(Cell Death);细胞膜(Cell Membrane);DNA损伤(DNA Damage);表位(Epitopes);女(雌)性(Female);磷脂酰肌醇蛋白聚糖类(Glypicans);人类(Humans);免疫轭合物(Immunoconjugates);肺肿瘤(Lung Neoplasms);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, SCID(Mice, SCID);神经母细胞瘤(Neuroblastoma);癌基因蛋白质类(Oncogene Proteins);蛋白质构象(Protein Conformation);小细胞肺癌(Small Cell Lung Carcinoma);小鼠(Mice)

DOI 10.1016/j.xcrm.2021.100344

PMID 34337560

发布时间 2024-05-06

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Cell reports. Medicine

2021年2卷7期

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A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.

Cell reports. Medicine

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A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.

Cell reports. Medicine

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Cell reports. Medicine

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