换一批The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.
第一作者：
Liam,Simms
第一单位：
Imperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
作者：
关键词
ATRA, All-trans-retinoic acidCDC, Centers for Disease Control and PreventionCOT, United Kingdom Committee on Toxicity of Chemicals in Food, Consumer Products and the EnvironmentCV, coefficient of variationCigarettesDART, developmental and reproductive toxicityDNPH, 2,4-dinitrophenylhydrazineDevelopmental toxicityE-cigarettesECVAM, European Center for the Validation of Alternative MethodsEPA, United States Environmental Protection AgencyEVP, electronic vapour productFDR, false discovery rateHPHCs, Harmful and Potentially Harmful ConstituentsHPLC-DAD, high-performance liquid chromatography with a diode-array detectorHTP, heated tobacco productHYB, hybrid productHuman induced pluripotent stem cellsISO, International Organization for StandardisationISTD, internal standardIn vitro reproduction assayLC-MS/MS, liquid chromatography with tandem mass spectrometryLOQ, limit of quantificationND, No effect was detected within the exposure range testedNHS, United Kingdom National Health ServiceNICE, National Institute for Health and Care ExcellenceNicotineODC, ornithine decarboxylaseOECD, Organisation for Economic Co-operation and DevelopmentPBS, phosphate buffered salinePG/VG, propylene glycol/vegetable glycerinePOD, point of differenceQ-TOF, Quadrupole Time-of-FlightROS, reactive oxygen speciesTP, cell viability toxicity potential concentrationTT21C, toxicity testing in the 21st centuryUPLC-HRMS, ultra-high performance liquid chromatography coupled high resolution mass spectrometrybPBS, bubbled phosphate buffered salinedTP, developmental toxicity potential concentrationdTT, developmental toxicity thresholddevTOXqP, devTOX quickPredicte-cigarettes, electronic cigarettesiPS cells, induced pluripotent stem cellsnAChRs, nicotinic acetylcholine receptorso/c, ornithine/cystine ratio
DOI
10.1016/j.crtox.2020.11.001
PMID
34345845
发布时间
2021-08-06
- 浏览2
Current research in toxicology
2020年1卷
161-173页
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