Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.

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作者： Lukasz,Czekala ^[1] ; Roman,Wieczorek ^[2] ; Liam,Simms ^[1] ; Fan,Yu ^[1] ; Jessica,Budde ^[2] ; Edgar,Trelles Sticken ^[2] ; Kathryn,Rudd ^[1] ; Thomas,Verron ^[1] ; Oleg,Brinster ^[2] ; Matthew,Stevenson ^[1] ; Tanvir,Walele ^[1]

作者单位： Imperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom. ^[1] Reemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany. ^[2]

关键词 2D, Two Dimensional 3D, Three Dimensional 3R4F, Scientific Reference Tobacco Cigarette (University of Kentucky)ALI, Air-Liquid Interface ANOVA, Analysis of Variance AOP, Adverse Outcome Pathway CAA, Cilia Active Area CBF, Cilia Beat Frequency COPD, Chronic Obstructive Pulmonary Disease CYP450, Cytochrome P450 Cigarette Cilia DPBS, Dulbecco's phosphate-buffered saline containing Ca2+ and Mg2+EGFR, Epidermal Growth Factor Receptor EVP, Electronic Vapor Product Electronic vapor product FOX-J1, Forkhead Box J1 protein H&E, Hematoxylin and Eosin IIVS, Institute for In Vitro Sciences IL-13, Interleukin 13 IL-1β, Interleukin 1 Beta IL-6, Interleukin-6 IL-8, Interleukin-8 ISO, International Organization for Standardization Immunohistochemistry KERs, Key Event Relationships KEs, Key Events LDH, Lactate Dehydrogenase MIE, Molecular Initiating Event MMP-1, Matrix Metalloproteinase-1 MMP-3, Matrix Metalloproteinase-3 MMP-9, Matrix Metalloproteinase-9 MUC5AC, Mucin 5AC Protein MWP, Multi-Well Plate NKT, Natural Killer T Cells Organotypic tissue model PBS, Phosphate Buffered Saline PMN, polymorphonuclear Pro-inflammatory markers SAEIVS, Smoke Aerosol Exposure In Vitro System TEER, Transepithelial Electrical Resistance THR, Tobacco Harm Reduction TNF-α, Tumor Necrosis Factor Alpha TPM, Total Particulate Matter

DOI 10.1016/j.crtox.2021.02.004

PMID 34345855

发布时间 2024-04-03

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Current research in toxicology

2021年2卷

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Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.

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Current research in toxicology

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Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.

Current research in toxicology

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Current research in toxicology

相关期刊

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