Evaluation of covariate effects using variance-based global sensitivity analysis in pharmacometrics.

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第一作者： Takayuki,Katsube

第一单位： Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd., Imabashi 3-3-13, Chuo-ku, Osaka, 541-0042, Japan. takayuki.katsube@shionogi.co.jp.

作者： Takayuki,Katsube ^[1] ; Toshihiro,Wajima ^[2]

作者单位： Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd., Imabashi 3-3-13, Chuo-ku, Osaka, 541-0042, Japan. takayuki.katsube@shionogi.co.jp. ^[1] Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd., Imabashi 3-3-13, Chuo-ku, Osaka, 541-0042, Japan.;Clinical Pharmacology, IDEC Inc, Nishi-Shinjuku 6-5-1, Shinjuku-ku, Tokyo, 163-1341, Japan. ^[2]

关键词 Covariate effect Non-linear mixed effects model Pharmacometrics Variance-based global sensitivity analysis

主题词方差分析(Analysis of Variance)

DOI 10.1007/s10928-021-09775-8

PMID 34347231

发布时间 2022-03-16

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