换一批
第一作者：
Katherine S,Ruth
第一单位：
Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
作者：
Katherine S,Ruth [1]
;
Felix R,Day [2]
;
Jazib,Hussain [3]
;
Ana,Martínez-Marchal [4]
;
Catherine E,Aiken [5]
;
Ajuna,Azad [3]
;
Deborah J,Thompson [6]
;
Lucie,Knoblochova [7]
;
Hironori,Abe [8]
;
Jane L,Tarry-Adkins [5]
;
Javier Martin,Gonzalez [9]
;
Pierre,Fontanillas [10]
;
Annique,Claringbould [11]
;
Olivier B,Bakker [12]
;
Patrick,Sulem [13]
;
Robin G,Walters [14]
;
Chikashi,Terao [15]
;
Sandra,Turon [16]
;
Momoko,Horikoshi [17]
;
Kuang,Lin [18]
;
N Charlotte,Onland-Moret [19]
;
Aditya,Sankar [3]
;
Emil Peter Thrane,Hertz [20]
;
Pascal N,Timshel [21]
;
Vallari,Shukla [3]
;
Rehannah,Borup [3]
;
Kristina W,Olsen [22]
;
Paula,Aguilera [23]
;
Mònica,Ferrer-Roda [4]
;
Yan,Huang [4]
;
Stasa,Stankovic [2]
;
Paul R H J,Timmers [24]
;
Thomas U,Ahearn [25]
;
Behrooz Z,Alizadeh [26]
;
Elnaz,Naderi [26]
;
Irene L,Andrulis [27]
;
Alice M,Arnold [28]
;
Kristan J,Aronson [29]
;
Annelie,Augustinsson [30]
;
Stefania,Bandinelli [31]
;
Caterina M,Barbieri [32]
;
Robin N,Beaumont [1]
;
Heiko,Becher [33]
;
Matthias W,Beckmann [34]
;
Stefania,Benonisdottir [13]
;
Sven,Bergmann [35]
;
Murielle,Bochud [36]
;
Eric,Boerwinkle [37]
;
Stig E,Bojesen [38]
;
Manjeet K,Bolla [6]
;
Dorret I,Boomsma [39]
;
Nicholas,Bowker [2]
;
Jennifer A,Brody [40]
;
Linda,Broer [41]
;
Julie E,Buring [42]
;
Archie,Campbell [43]
;
Harry,Campbell [44]
;
Jose E,Castelao [45]
;
Eulalia,Catamo [46]
;
Stephen J,Chanock [25]
;
Georgia,Chenevix-Trench [47]
;
Marina,Ciullo [48]
;
Tanguy,Corre [49]
;
Fergus J,Couch [50]
;
Angela,Cox [51]
;
Laura,Crisponi [52]
;
Simon S,Cross [53]
;
Francesco,Cucca [54]
;
Kamila,Czene [55]
;
George Davey,Smith [56]
;
Eco J C N,de Geus [39]
;
Renée,de Mutsert [57]
;
Immaculata,De Vivo [58]
;
Ellen W,Demerath [59]
;
Joe,Dennis [6]
;
Alison M,Dunning [60]
;
Miriam,Dwek [61]
;
Mikael,Eriksson [62]
;
Tõnu,Esko [63]
;
Peter A,Fasching [64]
;
Jessica D,Faul [65]
;
Luigi,Ferrucci [66]
;
Nora,Franceschini [67]
;
Timothy M,Frayling [1]
;
Manuela,Gago-Dominguez [68]
;
Massimo,Mezzavilla [69]
;
Montserrat,García-Closas [25]
;
Christian,Gieger [70]
;
Graham G,Giles [71]
;
Harald,Grallert [70]
;
Daniel F,Gudbjartsson [13]
;
Vilmundur,Gudnason [72]
;
Pascal,Guénel [73]
;
Christopher A,Haiman [74]
;
Niclas,Håkansson [75]
;
Per,Hall [55]
;
Caroline,Hayward [76]
;
Chunyan,He [77]
;
Wei,He [62]
;
Gerardo,Heiss [67]
;
Miya K,Høffding [3]
;
John L,Hopper [78]
;
Jouke J,Hottenga [39]
;
Frank,Hu [79]
;
David,Hunter [80]
;
Mohammad A,Ikram [81]
;
Rebecca D,Jackson [82]
;
Micaella D R,Joaquim [1]
;
Esther M,John [83]
;
Peter K,Joshi [44]
;
David,Karasik [84]
;
Sharon L R,Kardia [85]
;
Christiana,Kartsonaki [14]
;
Robert,Karlsson [62]
;
Cari M,Kitahara [86]
;
Ivana,Kolcic [87]
;
Charles,Kooperberg [88]
;
Peter,Kraft [89]
;
Allison W,Kurian [83]
;
Zoltan,Kutalik [90]
;
Martina,La Bianca [46]
;
Genevieve,LaChance [91]
;
Claudia,Langenberg [2]
;
Lenore J,Launer [92]
;
Joop S E,Laven [93]
;
Deborah A,Lawlor [56]
;
Loic,Le Marchand [94]
;
Jingmei,Li [55]
;
Annika,Lindblom [95]
;
Sara,Lindstrom [96]
;
Tricia,Lindstrom [97]
;
Martha,Linet [86]
;
YongMei,Liu [98]
;
Simin,Liu [99]
;
Jian'an,Luan [2]
;
Reedik,Mägi [100]
;
Patrik K E,Magnusson [62]
;
Massimo,Mangino [101]
;
Arto,Mannermaa [102]
;
Brumat,Marco [69]
;
Jonathan,Marten [76]
;
Nicholas G,Martin [103]
;
Hamdi,Mbarek [39]
;
Barbara,McKnight [28]
;
Sarah E,Medland [103]
;
Christa,Meisinger [104]
;
Thomas,Meitinger [105]
;
Cristina,Menni [91]
;
Andres,Metspalu [100]
;
Lili,Milani [100]
;
Roger L,Milne [71]
;
Grant W,Montgomery [106]
;
Dennis O,Mook-Kanamori [107]
;
Antonella,Mulas [52]
;
Anna M,Mulligan [108]
;
Alison,Murray [109]
;
Mike A,Nalls [110]
;
Anne,Newman [111]
;
Raymond,Noordam [112]
;
Teresa,Nutile [113]
;
Dale R,Nyholt [114]
;
Andrew F,Olshan [115]
;
Håkan,Olsson [30]
;
Jodie N,Painter [103]
;
Alpa V,Patel [116]
;
Nancy L,Pedersen [62]
;
Natalia,Perjakova [100]
;
Annette,Peters [117]
;
Ulrike,Peters [88]
;
Paul D P,Pharoah [118]
;
Ozren,Polasek [119]
;
Eleonora,Porcu [52]
;
Bruce M,Psaty [40]
;
Iffat,Rahman [120]
;
Gad,Rennert [121]
;
Hedy S,Rennert [121]
;
Paul M,Ridker [42]
;
Susan M,Ring [56]
;
Antonietta,Robino [46]
;
Lynda M,Rose [122]
;
Frits R,Rosendaal [57]
;
Jacques,Rossouw [123]
;
Igor,Rudan [44]
;
Rico,Rueedi [35]
;
Daniela,Ruggiero [48]
;
Cinzia F,Sala [32]
;
Emmanouil,Saloustros [124]
;
Dale P,Sandler [125]
;
Serena,Sanna [52]
;
Elinor J,Sawyer [126]
;
Chloé,Sarnowski [127]
;
David,Schlessinger [128]
;
Marjanka K,Schmidt [129]
;
Minouk J,Schoemaker [130]
;
Katharina E,Schraut [131]
;
Christopher,Scott [97]
;
Saleh,Shekari [1]
;
Amruta,Shrikhande [3]
;
Albert V,Smith [72]
;
Blair H,Smith [132]
;
Jennifer A,Smith [85]
;
Rossella,Sorice [113]
;
Melissa C,Southey [133]
;
Tim D,Spector [91]
;
John J,Spinelli [134]
;
Meir,Stampfer [79]
;
Doris,Stöckl [135]
;
Joyce B J,van Meurs [41]
;
Konstantin,Strauch [136]
;
Unnur,Styrkarsdottir [13]
;
Anthony J,Swerdlow [137]
;
Toshiko,Tanaka [66]
;
Lauren R,Teras [116]
;
Alexander,Teumer [138]
;
Unnur,Þorsteinsdottir [139]
;
Nicholas J,Timpson [56]
;
Daniela,Toniolo [32]
;
Michela,Traglia [32]
;
Melissa A,Troester [115]
;
Thérèse,Truong [73]
;
Jessica,Tyrrell [1]
;
André G,Uitterlinden [140]
;
Sheila,Ulivi [46]
;
Celine M,Vachon [141]
;
Veronique,Vitart [76]
;
Uwe,Völker [142]
;
Peter,Vollenweider [143]
;
Henry,Völzke [138]
;
Qin,Wang [6]
;
Nicholas J,Wareham [2]
;
Clarice R,Weinberg [144]
;
David R,Weir [65]
;
Amber N,Wilcox [25]
;
Ko Willems,van Dijk [145]
;
Gonneke,Willemsen [39]
;
James F,Wilson [24]
;
Bruce H R,Wolffenbuttel [146]
;
Alicja,Wolk [147]
;
Andrew R,Wood [1]
;
Wei,Zhao [85]
;
Marek,Zygmunt [148]
;
Biobank-based Integrative Omics Study (BIOS) Consortium [14]
;
eQTLGen Consortium [149]
;
Biobank Japan Project [150]
;
China Kadoorie Biobank Collaborative Group [151]
;
kConFab Investigators [152]
;
LifeLines Cohort Study [21]
;
InterAct consortium [153]
;
23andMe Research Team [154]
;
Zhengming,Chen [16]
;
Liming,Li [23]
;
Lude,Franke [155]
;
Stephen,Burgess [139]
;
Patrick,Deelen [156]
;
Tune H,Pers [19]
;
Marie Louise,Grøndahl [157]
;
Claus Yding,Andersen [42]
;
Anna,Pujol [118]
;
Andres J,Lopez-Contreras [41]
;
Jeremy A,Daniel [158]
;
Kari,Stefansson [8]
;
Jenny,Chang-Claude [159]
;
Yvonne T,van der Schouw [160]
;
Kathryn L,Lunetta [161]
;
Daniel I,Chasman [162]
;
Douglas F,Easton [163]
;
Jenny A,Visser [164]
;
Susan E,Ozanne [165]
;
Satoshi H,Namekawa ;
Petr,Solc ;
Joanne M,Murabito ;
Ken K,Ong ;
Eva R,Hoffmann ;
Anna,Murray ;
Ignasi,Roig ;
John R B,Perry
作者单位：
Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
[1]
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
[2]
DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[3]
Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.;Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
[4]
University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.;Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
[5]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[6]
Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic.;Faculty of Science, Charles University, Prague, Czech Republic.
[7]
Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
[8]
Transgenic Core Facility, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[9]
23andMe Inc., Sunnyvale, CA, USA.
[10]
Structural and Computational Biology Unit, EMBL, Heidelberg, Germany.
[11]
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
[12]
deCODE genetics/Amgen, Reykjavik, Iceland.
[13]
Nuffield Department of Population Health, University of Oxford, Oxford, UK.;MRC Population Health Research Unit, University of Oxford, Oxford, UK.
[14]
Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.;Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
[15]
Transgenic Animal Unit, Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
[16]
Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
[17]
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
[18]
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
[19]
DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[20]
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[21]
DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Reproductive Medicine, Department of Obstetrics and Gynaecology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
[22]
DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Sevilla -Universidad Pablo de Olavide, Seville, Spain.
[23]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.;MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
[24]
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
[25]
Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
[26]
Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
[27]
Department of Biostatistics, University of Washington, Seattle, WA, USA.
[28]
Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.;Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.
[29]
Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
[30]
Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
[31]
Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
[32]
Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[33]
Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
[34]
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.;Swiss Institute of Bioinformatics, Lausanne, Switzerland.
[35]
University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
[36]
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
[37]
Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.;Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.;Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[38]
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.;Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands.
[39]
Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
[40]
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
[41]
Brigham and Women's Hospital, Boston, MA, USA.;Harvard Medical School, Boston, MA, USA.
[42]
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
[43]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
[44]
Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.
[45]
Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
[46]
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
[47]
Institute of Genetics and Biophysics - CNR, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy.
[48]
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.;Swiss Institute of Bioinformatics, Lausanne, Switzerland.;University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
[49]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
[50]
Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
[51]
Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
[52]
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
[53]
Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.;University of Sassari, Department of Biomedical Sciences, Sassari, Italy.
[54]
Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
[55]
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
[56]
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
[57]
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.;Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
[58]
Division of Epidemiology & Community Health, University of Minnesotta, Minneapolis, MN, USA.
[59]
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
[60]
School of Life Sciences, University of Westminster, London, UK.
[61]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[62]
Population and Medical Genetics, Broad Institute, Cambridge, MA, USA.;Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
[63]
Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.;David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA.
[64]
Survey Research Center, Institute for Social Research, Ann Arbor, MI, USA.
[65]
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
[66]
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
[67]
Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
[68]
Department of Medical Sciences, University of Trieste, Trieste, Italy.
[69]
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.
[70]
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.;Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
[71]
Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[72]
Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
[73]
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[74]
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
[75]
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
[76]
Division of Medical Oncology, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.;The Cancer Prevention and Control Research Program, University of Kentucky Markey Cancer Center, Lexington, KY, USA.
[77]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
[78]
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.;Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.;Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
[79]
Nuffield Department of Population Health, University of Oxford, Oxford, UK.;Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.;Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.;Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.;Broad Institute of Harvard and MIT, Cambridge, MA, USA.
[80]
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
[81]
Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
[82]
Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.;Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
[83]
Harvard Medical School, Boston, MA, USA.;Hebrew SeniorLife Institute for Aging Research, Boston, MA, USA.
[84]
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
[85]
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
[86]
Faculty of Medicine, University of Split, Split, Croatia.
[87]
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
[88]
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.;Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
[89]
Swiss Institute of Bioinformatics, Lausanne, Switzerland.;University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
[90]
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
[91]
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
[92]
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands.
[93]
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
[94]
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.;Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
[95]
Department of Epidemiology, University of Washington, Seattle, WA, USA.
[96]
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
[97]
Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Wake Forest, NC, USA.
[98]
Department of Epidemiology, Brown University, Providence, RI, USA.;Department of Medicine, Brown University, Providence, RI, USA.
[99]
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
[100]
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.;NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK.
[101]
Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.;Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.;Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
[102]
QIMR Berghofer Medical Research Insititute, Brisbane, Queensland, Australia.
[103]
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany.
[104]
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
[105]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
[106]
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.;Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
[107]
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.;Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
[108]
The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
[109]
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
[110]
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
[111]
Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
[112]
Institute of Genetics and Biophysics - CNR, Naples, Italy.
[113]
Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
[114]
Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[115]
Department of Population Science, American Cancer Society, Atlanta, GA, USA.
[116]
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.
[117]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
[118]
Faculty of Medicine, University of Split, Split, Croatia.;Gen-Info Ltd, Zagreb, Croatia.
[119]
Quantify Research, Stockholm, Sweden.
[120]
Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
[121]
Brigham and Women's Hospital, Boston, MA, USA.
[122]
Women's Health Initiative Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
[123]
Department of Oncology, University Hospital of Larissa, Larissa, Greece.
[124]
Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
[125]
School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, UK.
[126]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[127]
National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
[128]
Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.;Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
[129]
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
[130]
Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.;Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.
[131]
Division of Population and Health Genomics, University of Dundee, Dundee, UK.
[132]
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.;Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.;Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
[133]
Population Oncology, BC Cancer, Vancouver, British Columbia, Canada.;School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
[134]
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.
[135]
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.;Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
[136]
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.;Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
[137]
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
[138]
deCODE genetics/Amgen, Reykjavik, Iceland.;Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
[139]
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.;Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
[140]
Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
[141]
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
[142]
Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
[143]
Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
[144]
Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.;Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.;Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
[145]
Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
[146]
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.;Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
[147]
Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.
[148]
School of Public Health, Peking University Health Science Center, Beijing, P.R. China.;Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, P.R. China.
[149]
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.;Oncode Institute, Utrecht, The Netherlands.
[150]
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
[151]
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.;Department of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.
[152]
Reproductive Medicine, Department of Obstetrics and Gynaecology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
[153]
Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[154]
The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[155]
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[156]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, USA.
[157]
University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
[158]
Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic.
[159]
NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, USA.;Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA, USA.
[160]
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.;Department of Paediatrics, University of Cambridge, Cambridge, UK.
[161]
DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. eva@sund.ku.dk.
[162]
Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. a.murray@exeter.ac.uk.
[163]
Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. ignasi.roig@uab.cat.;Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. ignasi.roig@uab.cat.
[164]
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.;Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. john.perry@mrc-epid.cam.ac.uk.
[165]
医学主题词
成年人(Adult);衰老(Aging);等位基因(Alleles);动物(Animals);骨和骨组织(Bone and Bones);糖尿病, 2型(Diabetes Mellitus, Type 2);膳食(Diet);欧洲(Europe);女(雌)性(Female);生育力(Fertility);脆性X智力低下蛋白质(Fragile X Mental Retardation Protein);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);长寿(Longevity);绝经期(Menopause);绝经, 过早(Menopause, Premature);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);中年人(Middle Aged);卵巢(Ovary);原发性卵巢功能不全(Primary Ovarian Insufficiency);子宫(Uterus)
DOI
10.1038/s41586-021-03779-7
PMID
34349265
发布时间
2025-07-22
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Nature
Nature
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