换一批
换一批Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors.
第一作者：
Philipp,Sievers
第一单位：
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
作者：
Philipp,Sievers [1]
;
Sophie C,Henneken [2]
;
Christina,Blume [3]
;
Martin,Sill [2]
;
Daniel,Schrimpf [1]
;
Damian,Stichel [1]
;
Konstantin,Okonechnikov [2]
;
David E,Reuss [1]
;
Julia,Benzel [2]
;
Kendra K,Maaß [4]
;
Marcel,Kool [5]
;
Dominik,Sturm [6]
;
Tuyu,Zheng [7]
;
David R,Ghasemi [2]
;
Patricia,Kohlhof-Meinecke [8]
;
Ofelia,Cruz [9]
;
Mariona,Suñol [10]
;
Cinzia,Lavarino [11]
;
Viktoria,Ruf [12]
;
Henning B,Boldt [13]
;
Mélanie,Pagès [14]
;
Celso,Pouget [15]
;
Leonille,Schweizer [16]
;
Mariëtte E G,Kranendonk [17]
;
Noreen,Akhtar [18]
;
Stephanie,Bunkowski [19]
;
Christine,Stadelmann [19]
;
Ulrich,Schüller [20]
;
Wolf C,Mueller [21]
;
Hildegard,Dohmen [22]
;
Till,Acker [22]
;
Patrick N,Harter [23]
;
Christian,Mawrin [24]
;
Rudi,Beschorner [25]
;
Sebastian,Brandner [26]
;
Matija,Snuderl [27]
;
Zied,Abdullaev [28]
;
Kenneth,Aldape [28]
;
Mark R,Gilbert [29]
;
Terri S,Armstrong [29]
;
David W,Ellison [30]
;
David,Capper [16]
;
Koichi,Ichimura [31]
;
Guido,Reifenberger [32]
;
Richard G,Grundy [33]
;
Nada,Jabado [34]
;
Lenka,Krskova [35]
;
Michal,Zapotocky [36]
;
Ales,Vicha [36]
;
Pascale,Varlet [37]
;
Pieter,Wesseling [38]
;
Stefan,Rutkowski [39]
;
Andrey,Korshunov [40]
;
Wolfgang,Wick [41]
;
Stefan M,Pfister [4]
;
David T W,Jones [42]
;
Andreas,von Deimling [1]
;
Kristian W,Pajtler [43]
;
Felix,Sahm [44]
作者单位：
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[1]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[2]
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.;Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[3]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
[4]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
[5]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.;Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.;Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[6]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.;Faculty of Biosciences, Heidelberg University, 69117, Heidelberg, Germany.
[7]
Department of Pathology, Klinikum Stuttgart, Stuttgart, Germany.
[8]
Department of Pediatric Oncology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
[9]
Department of Pathology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
[10]
Laboratory of Molecular Oncology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
[11]
Institute of Neuropathology, Ludwig-Maximilian University, Munich, Germany.
[12]
Department of Pathology, Odense University Hospital, Odense, Denmark.;Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
[13]
Department of Neuropathology, GHU Paris Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris, France.;Laboratory of Translational Research in Pediatric Oncology, SIREDO, INSERM U830, Institut Curie, Paris Sciences Lettres University, Paris, France.
[14]
Department of Pathology, CHRU, Nancy, France.
[15]
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neuropathology, Berlin, Germany.;German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[16]
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.;Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
[17]
Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK.;Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
[18]
Institute for Neuropathology, University Medical Centre Göttingen, Göttingen, Germany.
[19]
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
[20]
Paul-Flechsig Institute of Neuropathology, University Hospital and Faculty of Medicine, Leipzig, Germany.
[21]
Institute of Neuropathology, University of Giessen, Giessen, Germany.
[22]
Frankfurt Cancer Institute (FCI), University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.;Institute of Neurology (Edinger-Institute), University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.;German Cancer Consortium (DKTK), Partner site Frankfurt/Mainz, Frankfurt am Main, Germany.;German Cancer Research Center (DKFZ), Heidelberg, Germany.
[23]
Department of Neuropathology, Otto-Von-Guericke University, Magdeburg, Germany.
[24]
Department of Neuropathology, University of Tübingen, Tübingen, Germany.
[25]
Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK.;Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
[26]
Department of Pathology, NYU Langone Medical Center, New York, NY, USA.
[27]
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
[28]
Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
[29]
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
[30]
Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
[31]
Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.;German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.
[32]
Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.
[33]
Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.;Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada.;The Research Institute of the McGill University Health Center, Montreal, QC, H4A 3J1, Canada.
[34]
Prague Brain Tumor Research Group, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.;Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
[35]
Prague Brain Tumor Research Group, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.;Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
[36]
Department of Neuropathology, GHU Paris Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris, France.
[37]
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.;Department of Pathology, Amsterdam University Medical Centers, Location VUmc and Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
[38]
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[39]
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.;Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
[40]
Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
[41]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.;Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[42]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. k.pajtler@kitz-heidelberg.de.;Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. k.pajtler@kitz-heidelberg.de.;Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany. k.pajtler@kitz-heidelberg.de.
[43]
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.;Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.;Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
[44]
主题词
细胞周期蛋白质类(Cell Cycle Proteins);儿童(Child);室管膜瘤(Ependymoma);女(雌)性(Female);人类(Humans);男(雄)性(Male);癌基因融合(Oncogene Fusion);幕上肿瘤(Supratentorial Neoplasms);转录因子(Transcription Factors);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1007/s00401-021-02356-6
PMID
34355256
发布时间
2022-02-22
- 浏览6
Acta neuropathologica
Acta neuropathologica
827-839页
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