Molecular basis for substrate recruitment to the PRMT5 methylosome.-论文-万方医学网

作者： Kathleen M,Mulvaney ^[1] ; Christa,Blomquist ^[1] ; Nischal,Acharya ^[1] ; Ruitong,Li ^[1] ; Matthew J,Ranaghan ^[2] ; Meghan,O'Keefe ^[2] ; Diego J,Rodriguez ^[1] ; Michael J,Young ^[1] ; Devishi,Kesar ^[1] ; Debjani,Pal ^[1] ; Matthew,Stokes ^[3] ; Alissa J,Nelson ^[3] ; Sidharth S,Jain ^[1] ; Annan,Yang ^[4] ; Zachary,Mullin-Bernstein ^[1] ; Josie,Columbus ^[1] ; Fazli K,Bozal ^[1] ; Adam,Skepner ^[2] ; Donald,Raymond ^[2] ; Salvatore,LaRussa ^[2] ; David C,McKinney ^[2] ; Yelena,Freyzon ^[1] ; Yossef,Baidi ^[1] ; Dale,Porter ^[5] ; Andrew J,Aguirre ^[6] ; Alessandra,Ianari ^[1] ; Brian,McMillan ^[7] ; William R,Sellers ^[8]

作者单位： Broad Institute, Cambridge, MA, USA. ^[1] Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA. ^[2] Cell Signaling Technologies, Danvers, MA, USA. ^[3] Tango Therapeutics, Cambridge, MA, USA. ^[4] Broad Institute, Cambridge, MA, USA; Cedilla Therapeutics, Cambridge, MA, USA. ^[5] Broad Institute, Cambridge, MA, USA; Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. ^[6] Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA; Tango Therapeutics, Cambridge, MA, USA. ^[7] Broad Institute, Cambridge, MA, USA; Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. Electronic address: wsellers@broadinstitute.org. ^[8]

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞质(Cytoplasm);女(雌)性(Female);HCT116细胞(HCT116 Cells);HEK293细胞(HEK293 Cells);组蛋白类(Histones);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);离子通道(Ion Channels);男(雄)性(Male);甲基化(Methylation);小鼠(Mice);小鼠, 裸(Mice, Nude);核蛋白质类(Nuclear Proteins);肽类(Peptides);蛋白质结合(Protein Binding);蛋白质加工, 转译后(Protein Processing, Post-Translational);蛋白质精氨酸N-甲基转移酶(Protein-Arginine N-Methyltransferases);剪接体(Spliceosomes)

DOI 10.1016/j.molcel.2021.07.019

PMID 34358446

发布时间 2022-09-03

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Molecular basis for substrate recruitment to the PRMT5 methylosome.

Molecular cell

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Molecular cell

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Molecular basis for substrate recruitment to the PRMT5 methylosome.

Molecular cell

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Molecular cell

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