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首页> Proceedings of the National Academy of Sciences of the United States of America> <i>Mycobacterium tuberculosis</i> VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response.

<i>Mycobacterium tuberculosis</i> VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response.

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作者： Valdir C,Barth ^[1] ; Unnati,Chauhan ^[1] ; Jumei,Zeng ^[2] ; Xiaoyang,Su ^[3] ; Haiyan,Zheng ^[4] ; Robert N,Husson ^[5] ; Nancy A,Woychik ^[6]

作者单位： Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854. ^[1] Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115. ^[2] Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08904. ^[3] Metabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08904. ^[4] Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08904. ^[5] Center for Integrative Proteomics Research, Rutgers University, Piscataway, NJ 08854. ^[6] Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854; nancy.woychik@rutgers.edu. ^[7]

关键词 RNA-seq mass spectrometry mycothiol protein translation sulfur assimilation

主题词细菌蛋白质类(Bacterial Proteins);细菌毒素类(Bacterial Toxins);铜(Copper);半胱氨酸(Cysteine);酶类(Enzymes);基因表达调控, 细菌(Gene Expression Regulation, Bacterial);宿主与病原体相互作用(Host-Pathogen Interactions);结核分枝杆菌(Mycobacterium tuberculosis);开放读码框架(Open Reading Frames);氧化性应激(Oxidative Stress);蛋白质生物合成(Protein Biosynthesis);RNA, 细菌(RNA, Bacterial);RNA, 转移, 半胱氨酸(RNA, Transfer, Cys);核糖体(Ribosomes);硫(Sulfur)

DOI 10.1073/pnas.2022136118

PMID 34362841

发布时间 2022-02-07

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2021年118卷32期

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2021年118卷32期

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