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Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives.

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第一作者： Liyu,Zhao

第一单位： Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.

作者： Liyu,Zhao ^[1] ; Wenbo,Yin ^[1] ; Yin,Sun ^[1] ; Nannan,Sun ^[1] ; Linfeng,Tian ^[1] ; Yang,Zheng ^[1] ; Chu,Zhang ^[1] ; Shizhen,Zhao ^[2] ; Xin,Su ^[3] ; Dongmei,Zhao ^[4] ; Maosheng,Cheng ^[1]

作者单位： Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. ^[1] Key Laboratory of Receptor-Mediated Gene Regulation and Drug Discovery, School of Medicine, Henan University, Kaifeng, 475004, China. ^[2] The School of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. ^[3] Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: medchemzhao@163.com. ^[4]

关键词 Azole antifungals CYP51 Dihydrooxazole derivatives Metabolic stability

医学主题词抗真菌药(Antifungal Agents);药物设计(Drug Design);人类(Humans);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2021.113715

PMID 34364163

发布时间 2022-01-10

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