Post-translational down-regulation of Nrf2 and YAP proteins, by targeting deubiquitinases, reduces growth and chemoresistance in pancreatic cancer cells.

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第一作者： Margherita,Grattarola

第一单位： Department of Clinical and Biological Science, University of Turin, Corso Raffaello 30, 10125, Torino, Italy.

作者： Margherita,Grattarola ^[1] ; Marie Angèle,Cucci ^[1] ; Antonella,Roetto ^[1] ; Chiara,Dianzani ^[2] ; Giuseppina,Barrera ^[1] ; Stefania,Pizzimenti ^[3]

作者单位： Department of Clinical and Biological Science, University of Turin, Corso Raffaello 30, 10125, Torino, Italy. ^[1] Department of Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125, Turin, Italy. ^[2] Department of Clinical and Biological Science, University of Turin, Corso Raffaello 30, 10125, Torino, Italy. Electronic address: stefania.pizzimenti@unito.it. ^[3]

关键词 Chemoresistance Deubiquitinases Nrf2 Oxidative stress PDAC cells YAP

主题词细胞系, 肿瘤(Cell Line, Tumor);减量调节(Down-Regulation);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);NF-E2相关因子2(NF-E2-Related Factor 2);胰腺肿瘤(Pancreatic Neoplasms)

DOI 10.1016/j.freeradbiomed.2021.08.006

PMID 34364982

发布时间 2021-09-09

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准确一般字义偏差语意偏离译文作用小提交