首页> Bioorganic chemistry> Neuropathic pain-alleviating activity of novel 5-HT<sub>6</sub> receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide.

Neuropathic pain-alleviating activity of novel 5-HT<sub>6</sub> receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide.

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第一作者： Marcin,Drop

第一单位： Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland; IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.

作者： Marcin,Drop ^[1] ; Florian,Jacquot ^[2] ; Vittorio,Canale ^[3] ; Severine,Chaumont-Dubel ^[4] ; Maria,Walczak ^[3] ; Grzegorz,Satała ^[5] ; Klaudia,Nosalska ^[3] ; Gilbert Umuhire,Mahoro ^[6] ; Karolina,Słoczyńska ^[3] ; Kamil,Piska ^[3] ; Sylvain,Lamoine ^[2] ; Elżbieta,Pękala ^[3] ; Nicolas,Masurier ^[6] ; Andrzej J,Bojarski ^[5] ; Maciej,Pawłowski ^[3] ; Jean,Martinez ^[6] ; Gilles,Subra ^[6] ; Xavier,Bantreil ^[6] ; Frédéric,Lamaty ^[6] ; Alain,Eschalier ^[2] ; Philippe,Marin ^[4] ; Christine,Courteix ^[2] ; Paweł,Zajdel ^[7]

作者单位： Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland; IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France. ^[1] Université Clermont Auvergne, INSERM U1107, NEURO-DOL, F-63000 Clermont-Ferrand, France. ^[2] Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland. ^[3] Institut de Génomique Fonctionelle, Université de Montpellier, CNRS INSERM, 34094 Montpellier, France. ^[4] Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland. ^[5] IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France. ^[6] Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland. Electronic address: pawel.zajdel@uj.edu.pl. ^[7]

关键词 5-HT(6) receptor inverse agonism Cdk5 signaling Flow chemistry Neuropathic pain Spinal nerve ligation mTOR kinase