首页> Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico> In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types.

In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types.

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第一作者： M D,Matossian

第一单位： Department of Medicine, Section of Hematology & Medical Oncology, Tulane University School of Medicine, New Orleans, LA, USA.

作者： M D,Matossian ^[1] ; T,Chang ^[1] ; M K,Wright ^[1] ; H E,Burks ^[1] ; S,Elliott ^[1] ; R A,Sabol ^[2] ; H,Wathieu ^[1] ; G O,Windsor ^[1] ; M S,Alzoubi ^[1] ; C T,King ^[3] ; J B,Bursavich ^[3] ; A M,Ham ^[3] ; J J,Savoie ^[3] ; K,Nguyen ^[1] ; M,Baddoo ^[4] ; E,Flemington ^[4] ; O,Sirenko ^[5] ; E F,Cromwell ^[6] ; K L,Hebert ^[1] ; F,Lau ^[7] ; R,Izadpanah ^[8] ; H,Brown ^[9] ; S,Sinha ^[9] ; J,Zabaleta ^[10] ; A I,Riker ^[11] ; K,Moroz ^[12] ; L,Miele ^[13] ; A H,Zea ^[14] ; A,Ochoa ^[13] ; B A,Bunnell ^[15] ; B M,Collins-Burow ^[16] ; E C,Martin ^[3] ; M E,Burow ^[17]

作者单位： Department of Medicine, Section of Hematology & Medical Oncology, Tulane University School of Medicine, New Orleans, LA, USA. ^[1] Tulane Center for Stem Cell Research and Regenerative Medicine, New Orleans, LA, USA. ^[2] Department of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, USA. ^[3] Cancer Genetics Program, Tulane University School of Medicine, New Orleans, LA, USA. ^[4] Molecular Devices LLC, San Jose, CA, USA. ^[5] Protein Fluidics Inc, Burlingame, CA, USA. ^[6] Department of Surgery, Section of Plastic & Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[7] Tulane Cancer Center, New Orleans, LA, USA. ^[8] Innogenomics Technologies LLC, New Orleans, LA, USA. ^[9] Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[10] Cancer Service Line, Anne Arundel Medical Center, Luminis Health, DeCesaris Cancer Institute, Annapolis, MD, USA. ^[11] Louisiana Cancer Research Center, Biospecimen Core, New Orleans, LA, USA.;Department of Pathology, Tulane University School of Medicine, New Orleans, LA, USA. ^[12] Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[13] Louisiana Cancer Research Center, Biospecimen Core, New Orleans, LA, USA.;Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[14] Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA. ^[15] Department of Medicine, Section of Hematology & Medical Oncology, Tulane University School of Medicine, New Orleans, LA, USA.;Tulane Cancer Center, New Orleans, LA, USA. ^[16] Department of Medicine, Section of Hematology & Medical Oncology, Tulane University School of Medicine, New Orleans, LA, USA. mburow@tulane.edu. ^[17]

关键词 Collagen Extracellular matrix Metaplastic breast carcinoma Patient-derived xenograft Triple negative breast cancer

医学主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);疾病模型, 动物(Disease Models, Animal);人类(Humans);模型, 生物学(Models, Biological);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1007/s12094-021-02677-8

PMID 34370182

发布时间 2026-02-05

基金项目

T34 GM136452/GM/NIGMS NIH HHS/United States R01 CA174785/CA/NCI NIH HHS/United States U54 GM104940/GM/NIGMS NIH HHS/United States T32 EB027632/EB/NIBIB NIH HHS/United States 1R15CA176496-01A1/NH/NIH HHS/United States R01-CA174785-A1/NH/NIH HHS/United States R01-CA125806-04/NH/NIH HHS/United States

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