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The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets.

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作者: Cornelis M,van Tilburg [1] ; Elke,Pfaff [2] ; Kristian W,Pajtler [3] ; Karin P S,Langenberg [4] ; Petra,Fiesel [5] ; Barbara C,Jones [6] ; Gnana Prakash,Balasubramanian [3] ; Sebastian,Stark [4] ; Pascal D,Johann [5] ; Mirjam,Blattner-Johnson [7] ; Kathrin,Schramm [6] ; Nicola,Dikow [3] ; Steffen,Hirsch [4] ; Christian,Sutter [5] ; Kerstin,Grund [8] ; Arend,von Stackelberg [9] ; Andreas E,Kulozik [4] ; Andrej,Lissat [5] ; Arndt,Borkhardt [10] ; Roland,Meisel [11] ; Dirk,Reinhardt [6] ; Jan-Henning,Klusmann [3] ; Gudrun,Fleischhack [4] ; Stephan,Tippelt [5] ; Dietrich,von Schweinitz [7] ; Irene,Schmid [6] ; Christof M,Kramm [4] ; André O,von Bueren [5] ; Gabriele,Calaminus [8] ; Peter,Vorwerk [6] ; Norbert,Graf [3] ; Frank,Westermann [4] ; Matthias,Fischer [5] ; Angelika,Eggert [7] ; Birgit,Burkhardt [6] ; Wilhelm,Wößmann [3] ; Michaela,Nathrath [4] ; Stefanie,Hecker-Nolting [5] ; Michael C,Frühwald [8] ; Dominik T,Schneider [12] ; Ines B,Brecht [6] ; Petra,Ketteler [4] ; Simone,Fulda [5] ; Ewa,Koscielniak [7] ; Michael T,Meister [6] ; Monika,Scheer [4] ; Simone,Hettmer [5] ; Matthias,Schwab [7] ; Roman,Tremmel [13] ; Ingrid,Øra [6] ; Caroline,Hutter [13] ; Nicolas U,Gerber [13] ; Olli,Lohi [13] ; Bernarda,Kazanowska [4] ; Antonis,Kattamis [5] ; Maria,Filippidou [14] ; Bianca,Goemans [6] ; C Michel,Zwaan [3] ; Till,Milde [4] ; Natalie,Jäger [5] ; Stephan,Wolf [15] ; David,Reuss [4] ; Felix,Sahm [5] ; Andreas,von Deimling [14] ; Uta,Dirksen [4] ; Angelika,Freitag [16] ; Ruth,Witt [4] ; Peter,Lichter [17] ; Annette,Kopp-Schneider [4] ; David T W,Jones [5] ; Jan J,Molenaar [18] ; David,Capper [19] ; Stefan M,Pfister [4] ; Olaf,Witt [5]
作者单位: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. cornelis.vantilburg@kitz-heidelberg.de. [1] Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany. [3] German Cancer Consortium (DKTK), Heidelberg, Germany. [4] National Center for Tumor Diseases (NCT) Network, Germany. [5] Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. [6] Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. [7] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [8] Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. [9] Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [10] Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. [11] Swabian Children's Cancer Center, Paediatric and Adolescent Medicine, University Medical Center Augsburg, Augsburg, Germany. [12] Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany. [13] Pediatric Oncology and Hematology Department, Charité-Campus Virchow Klinikum, Berlin, Germany. [14] Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ), Heidelberg, Germany. [15] Department of Pediatric Oncology and Hematology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. [16] Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. [17] West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany. [18] Department of Pediatric Hematology, Oncology and Hemostaseology, Clinic for Pediatrics, University Hospital of Frankfurt, Goethe-University Frankfurt, Frankfurt/Main, Germany. [19] Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany. [20] Department of Pediatric Oncology and Hematology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany. [21] Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany. [22] Department of Pediatrics, Obstetrics and Gynecology, Division of Pediatric Hematology and Oncology, University Hospital Geneva, Geneva, Switzerland. [23] Department of Pediatric Oncology and Hematology, University Hospital Bonn, Bonn, Germany. [24] Department of Pediatric Oncology and Hematology, University Hospital Magdeburg, Magdeburg, Germany. [25] Department of Pediatric Oncology and Hematology, University Hospital Saarland, Saarland, Germany. [26] Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. [27] Department of Experimental Pediatric Oncology, University Hospital Köln, and Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany. [28] Clinic of Pediatric Oncology and Hematology, University Hospital Münster, Muenster, Germany. [29] Department of Pediatric Oncology and Hematology, University Hospital Hamburg, Hamburg, Germany. [30] Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany. [31] Department of Pediatrics, Technical University Munich, Munich, Germany. [32] Department of Pediatric Oncology, Hematology and Immunology, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany. [33] Clinic of Pediatrics, Municipal Hospital Dortmund, Dortmund, Germany. [34] Department of Pediatric Oncology and Hematology, University Hospital Tübingen, Tübingen, Germany. [35] Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Frankfurt, Germany. [36] Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. [37] Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. [38] Departments of Clinical Pharmacology, Pharmacy and Biochemistry, and Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. [39] Department of Pediatric Oncology and Hematology, Skane University Hospital Lund, and HOPE-ITCC Unit, Pediatric Oncology, Karolinska University Hospital, Stockholm, Sweden. [40] St. Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, and St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. [41] Department of Oncology, University Children's Hospital, Zurich, Switzerland. [42] Tampere Center for Child Health Research and Tays Cancer Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. [43] Department of Pediatric Hematology/Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland. [44] Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece. [45] Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands. [46] Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany. [47] NCT Trial Center, National Center for Tumor Diseases, Heidelberg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany. [48] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. [49] Department Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany. [50] Utrecht University, Department of Pharmaceutical Sciences, Utrecht, the Netherlands. [51] Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany. [52]
DOI 10.1158/2159-8290.CD-21-0094
PMID 34373263
发布时间 2023-01-25
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