Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.

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第一作者： Joris,van de Haar

第一单位： Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

作者： Joris,van de Haar ^[1] ; Louisa R,Hoes ^[2] ; Paul,Roepman ^[3] ; Martijn P,Lolkema ^[1] ; Henk M W,Verheul ^[3] ; Hans,Gelderblom ^[4] ; Adrianus J,de Langen ^[5] ; Egbert F,Smit ^[6] ; Edwin,Cuppen ^[7] ; Lodewyk F A,Wessels ^[8] ; Emile E,Voest ^[8]

作者单位： Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands. ^[1] Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. ^[2] Oncode Institute, Amsterdam, the Netherlands. ^[3] Hartwig Medical Foundation, Amsterdam, the Netherlands. ^[4] Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands. ^[5] Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands. ^[6] Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands. ^[7] Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. ^[8] Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. ^[9] Faculty of EEMCS, Delft University of Technology, Delft, the Netherlands. ^[10] Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands. e.voest@nki.nl. ^[11] Oncode Institute, Amsterdam, the Netherlands. e.voest@nki.nl. ^[12] Center for Personalized Cancer Treatment, Rotterdam, the Netherlands. e.voest@nki.nl. ^[13]