Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study.
作者:
Roderick C,Slieker [1]
;
Louise A,Donnelly [2]
;
Hugo,Fitipaldi [3]
;
Gerard A,Bouland [4]
;
Giuseppe N,Giordano [1]
;
Mikael,Åkerlund [4]
;
Mathias J,Gerl [4]
;
Emma,Ahlqvist [5]
;
Ashfaq,Ali [4]
;
Iulian,Dragan [6]
;
Petra,Elders [7]
;
Andreas,Festa [8]
;
Michael K,Hansen [9]
;
Amber A,van der Heijden [10]
;
Dina,Mansour Aly [11]
;
Min,Kim [8]
;
Dmitry,Kuznetsov [4]
;
Florence,Mehl [6]
;
Christian,Klose [12]
;
Kai,Simons [7]
;
Imre,Pavo [7]
;
Timothy J,Pullen [5]
;
Tommi,Suvitaival [5]
;
Asger,Wretlind [9]
;
Peter,Rossing [13]
;
Valeriya,Lyssenko [14]
;
Cristina,Legido Quigley [6]
;
Leif,Groop [6]
;
Bernard,Thorens [6]
;
Paul W,Franks [15]
;
Mark,Ibberson [16]
;
Guy A,Rutter [17]
;
Joline W J,Beulens [6]
;
Leen M,'t Hart [11]
;
Ewan R,Pearson [4]
作者单位:
Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
[1]
Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.
[2]
Population Health & Genomics, School of Medicine, University of Dundee, Dundee, U.K.
[3]
Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, SUS, Malmö, Sweden.
[4]
Lipotype GmbH, Dresden, Germany.
[5]
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
[6]
Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
[7]
Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.
[8]
Eli Lilly Regional Operations GmbH, Vienna, Austria.
[9]
1st Medical Department, LK Stockerau, Niederösterreich, Austria.
[10]
Cardiovascular and Metabolic Disease Research, Janssen Research & Development, Spring House, PA.
[11]
Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicines, King's College London, London, U.K.
[12]
Department of Diabetes, Guy's Campus, King's College London, London, U.K.
[13]
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, U.K.
[14]
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
[15]
Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.
[16]
Genomics, Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
[17]
Finnish Institute of Molecular Medicine, Helsinki University, Helsinki, Finland.
[18]
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
[19]
Department of Nutrition, Harvard School of Public Health, Boston, MA.
[20]
Lee Kong Chian School of Medicine, Nan Yang Technological University, Singapore.
[21]
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
[22]
Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands lmthart@lumc.nl e.z.pearson@dundee.ac.uk.
[23]
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
[24]
Population Health & Genomics, School of Medicine, University of Dundee, Dundee, U.K. lmthart@lumc.nl e.z.pearson@dundee.ac.uk.
[25]
主题词
聚类分析(Cluster Analysis);队列研究(Cohort Studies);横断面研究(Cross-Sectional Studies);糖尿病, 2型(Diabetes Mellitus, Type 2);人类(Humans);胰岛素抗药性(Insulin Resistance)
DOI
10.2337/db20-1281
PMID
34376475
发布时间
2021-12-29
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Diabetes
Diabetes
2683-2693页
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