NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation.-论文-万方医学网

作者： Huibing,Wang ^[1] ; Weiwei,Qi ^[2] ; Chengyu,Zou ^[1] ; Zhangdan,Xie ^[2] ; Mengmeng,Zhang ^[2] ; Masanori Gomi,Naito ^[1] ; Lauren,Mifflin ^[1] ; Zhen,Liu ^[2] ; Ayaz,Najafov ^[1] ; Heling,Pan ^[2] ; Bing,Shan ^[2] ; Ying,Li ^[2] ; Zheng-Jiang,Zhu ^[2] ; Junying,Yuan ^[3]

作者单位： Department of Cell Biology, Harvard Medical School, Boston, MA, USA. ^[1] Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. ^[2] Department of Cell Biology, Harvard Medical School, Boston, MA, USA. junying_yuan@sioc.ac.cn. ^[3] Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. junying_yuan@sioc.ac.cn. ^[4]

主题词动物(Animals);动物, 新生(Animals, Newborn);血脑屏障(Blood-Brain Barrier);细胞系(Cell Line);细胞, 培养的(Cells, Cultured);细胞因子类(Cytokines);酶激活(Enzyme Activation);葡萄糖(Glucose);HEK293细胞(HEK293 Cells);人类(Humans);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小神经胶质细胞(Microglia);多蛋白复合物(Multiprotein Complexes);磷酰化(Phosphorylation);蛋白质转运(Protein Transport);RNA, 信使(RNA, Messenger);受体作用蛋白丝氨酸苏氨酸激酶类(Receptor-Interacting Protein Serine-Threonine Kinases);膜泡运输蛋白质类(Vesicular Transport Proteins);小鼠(Mice)

DOI 10.1038/s41467-021-25157-7

PMID 34376696

发布时间 2024-02-26

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NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation.

Nature communications

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Nature communications

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NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation.

Nature communications

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Nature communications

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