换一批
换一批Determination of benchmark doses for linear furanocoumarin consumption associated with inhibition of cytochrome P450 1A2 isoenzyme activity in healthy human adults.
第一作者：
Zeyad,Alehaideb
第一单位：
King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.;King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
作者：
关键词
5-MOP, 5-methoxypsoralen8-MOP, 8-methoxypsoralenAIC, Akaike’s information criterionBMD, benchmark doseBMDL, BMD lower boundBMDS, BMD softwareBMDU, BMD upper boundBMR, benchmark responseBenchmark doseCA, concentration-addition modelCYP, cytochrome P450CaffeineCytochrome 1A2 enzymeDMSO, dimethyl sulfoxideFuranocoumarinHLM, human liver microsomesHPLC, high-performance liquid chromatographyIC50, concentration at 50 inhibitionISOP, isopimpinellinLOAEL, lowest-observed-adverse-effect levelMetabolismNADPH, β-nicotinamide adenine dinucleotide phosphate hydrogenNOAEL, no-observed-adverse-effect levelPOD, point-of-departureRPF, relative potency factorSD, standard deviationTCL, treated clearanceTHM, traditional herbal medicineTraditional herbal medicinesUCL, untreated clearanceUSEPA, United States Environmental Protection AgencyWM, whole-mixture modellog10, common log
DOI
10.1016/j.toxrep.2021.07.013
PMID
34377680
发布时间
2021-08-12
- 浏览2
Toxicology reports
2021年8卷
1437-1444页
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