Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses.

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作者： Maria,Grazia Martina ^[1] ; Ilaria,Vicenti ^[2] ; Lisa,Bauer ^[3] ; Emmanuele,Crespan ^[4] ; Enrico,Rango ^[5] ; Adele,Boccuto ^[6] ; Noemi,Olivieri ^[7] ; Matteo,Incerti ^[2] ; Marleen,Zwaagstra ^[1] ; Marika,Allodi ^[1] ; Simona,Bertoni ^[3] ; Elena,Dreassi ^[1] ; Maurizio,Zazzi ^[1] ; Frank J M,van Kuppeveld ^[6] ; Giovanni,Maga ^[2] ; Marco,Radi ^[3]

作者单位： Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze, 27/A, 43124, Parma, Italy. ^[1] Department of Medical Biotechnologies, University of Siena, 53100, Siena, Italy. ^[2] Virology Section, Infectious Disease and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. ^[3] Current address: Department of Viroscience, Erasmus Medical Center, 3015CA, Rotterdam, The Netherlands. ^[4] Istituto di Genetica Molecolare, IGM-CNR "Luigi Luca Cavalli-Sforza", Via Abbiategrasso 207, 27100, Pavia, Italy. ^[5] Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100, Siena, Italy. ^[6] Current address: Dipartimento di Farmacia, Università degli Studi di Genova, 16132, Genoa, Italy. ^[7]

关键词 Broad-spectrum antivirals PI4KIIIb SARS-CoV-2 bithiazole rhinovirus zika virus