The toxicity of Aspidosperma subincanum to MCF7 cells is related to modulation of oxidative status and proinflammatory pathways.

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第一作者： Andressa F,Santos

第一单位： Postgraduate Program in Pharmaceutical Sciences, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil.

作者： Andressa F,Santos ^[1] ; Nádia S R,Santos Mota ^[2] ; Elberth M,Schiefer ^[3] ; Regiane S,da Cunha ^[4] ; Allan M,Junkert ^[1] ; Andréa E M,Stinghen ^[4] ; Roberto,Pontarolo ^[1] ; Amanda R,Crisma ^[5] ; Almeriane M,Weffort-Santos ^[5] ; Rozangela C,Pedrosa ^[2] ; Wesley M,de Souza ^[1] ; Karina B,Felipe ^[6]

作者单位： Postgraduate Program in Pharmaceutical Sciences, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil. ^[1] Laboratory of Experimental Biochemistry, Department of Biochemistry, Federal University of Santa Catarina, 88037-000, Florianópolis, SC, Brazil. ^[2] Postgraduate Program in Electrical and Computer Engineering, Federal Technological University of Paraná, 80230-901, Curitiba, PR, Brazil. ^[3] Experimental Nephrology Laboratory, Department of Basic Pathology, Federal University of Paraná, 81530-000, Curitiba, PR, Brazil. ^[4] Laboratory of Physiology and Cell Signaling, Department of Clinical Analyses, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil. ^[5] Postgraduate Program in Pharmaceutical Sciences, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil; Laboratory of Physiology and Cell Signaling, Department of Clinical Analyses, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil. Electronic address: karinabettega@ufpr.br. ^[6]

关键词 Antiproliferative effect Aspidosperma subincanum Cyclooxygenase 2 Cytotoxicity IL-8 Reactive oxygen species