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Recent advances in nanomedicines for the treatment of ischemic stroke.

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第一作者: Chao,Li
第一单位: Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Research Center on Aging and Medicine, Fudan University, Shanghai 201203, China.
作者: Chao,Li [1] ; Tao,Sun [1] ; Chen,Jiang [1]
作者单位: Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Research Center on Aging and Medicine, Fudan University, Shanghai 201203, China. [1]
关键词 AEPO, asialo-erythropoietinAPOE, apolipoprotein EBBB, blood?brain barrierBCECs, brain capillary endothelial cellsBlood?brain barrierCAT, catalaseCOX-1, cyclooxygenase-1CXCR-4, C-X-C chemokine receptor type 4Ce-NPs, ceria nanoparticlesCsA, cyclosporine ADAMPs, damage-associated molecular patternsGFs, growth factorsGPIIb/IIIa, glycoprotein IIb/IIIaHMGB1, high mobility group protein B1Hb, hemoglobinICAM-1, intercellular adhesion molecule-1IL-1β, interleukin-1βIL-6, interleukin-6Ischemic cascadeLFA-1, lymphocyte function-associated antigen-1LHb, liposomal HbMCAO, middle cerebral artery occlusionMMPs, matrix metalloproteinasesMSC, mesenchymal stem cellNF-κB, nuclear factor-κBNGF, nerve growth factorNMDAR, N-methyl-d-aspartate receptorNOS, nitric oxide synthaseNPs, nanoparticlesNSCs, neural stem cellsNanomedicineNeuroprotectantPBCA, poly-butylcyanoacrylatePCMS, poly (chloromethylstyrene)PEG, poly-ethylene-glycolPEG-PLA, poly (ethylene-glycol)-b-poly (lactide)PLGA NPs, poly (l-lactide-co-glycolide) nanoparticlesPSD-95, postsynaptic density protein-95PSGL-1, P-selectin glycoprotein ligand-1RBCs, red blood cellsRES, reticuloendothelial systemRGD, Arg-Gly-AspROS, reactive oxygen speciesReperfusionSDF-1, stromal cell-derived factor-1SHp, stroke homing peptideSOD, superoxide dismutaseSUR1-TRPM4, sulfonylurea receptor 1-transient receptor potential melastatin-4StrokeTEMPO, 2,2,6,6-tetramethylpiperidine-1-oxylTIA, transient ischemic attackTNF-α, tumor necrosis factor-αThrombolyticscRGD, cyclic Arg-Gly-Aspe-PAM-R, arginine-poly-amidoamine esteriNOS, inducible nitric oxide synthasemiRNAs, microRNAsnNOS, neuron nitric oxide synthasesiRNA, small interfering RNA
DOI 10.1016/j.apsb.2020.11.019
PMID 34386320
发布时间 2021-08-14
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Acta pharmaceutica Sinica. B

Acta pharmaceutica Sinica. B

2021年11卷7期

1767-1788页

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